Structured Summary
Abstract
A subcomponent of complement C1, composed of six copies of three polypeptide chains (A, B, and C), each encoded by a separate gene (C1QA; C1QB; C1QC). This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY.
MeSH Record
Classification
Broader headings
Related Concepts
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
6 entry terms
- C1q Complement
- Complement 1q
- Complement Component 1q
- C1q, Complement
- Complement, C1q
- Component 1q, Complement
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2006 (1990)
MeSH Record
Previous Indexing
- Complement 1 (1980-1989)
- Complement Activating Enzymes (1979-1989)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Complement C1q. Medical Subject Headings (MeSH). 2026. Unique ID D015922. http://id.nlm.nih.gov/mesh/2026/D015922
- Complement C1q. In: Wikipedia. https://en.wikipedia.org/wiki/Complement_component_1q
- Complement C1q. In: Wikidata. https://www.wikidata.org/wiki/Q21116899