Structured Summary
Abstract
The first complement component to act in the activation of CLASSICAL COMPLEMENT PATHWAY. It is a calcium-dependent trimolecular complex made up of three subcomponents: COMPLEMENT C1Q; COMPLEMENT C1R; and COMPLEMENT C1S at 1:2:2 ratios. When the intact C1 binds to at least two antibodies (involving C1q), C1r and C1s are sequentially activated, leading to subsequent steps in the cascade of COMPLEMENT ACTIVATION.
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Classification
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
6 entry terms
- C1 Complement
- Complement 1
- Complement Component 1
- C1, Complement
- Complement, C1
- Component 1, Complement
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
Indexing Annotation
/antag permitted but consider also COMPLEMENT C1 INACTIVATOR PROTEINS
MeSH Record
History Note
2006 (1975)
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Previous Indexing
- Calcium (1966-1974)
- Complement (1968-1974)
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MeSH Record
NLM Classification
QW 680
AMA Style
References
- National Library of Medicine. Complement C1. Medical Subject Headings (MeSH). 2026. Unique ID D003172. http://id.nlm.nih.gov/mesh/2026/D003172
- Complement C1. In: Wikipedia. https://en.wikipedia.org/wiki/C1_complex
- Complement C1. In: Wikidata. https://www.wikidata.org/wiki/Q48834949