Chemicals and Drugs

Colchicine

A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (PERIODIC DISEASE).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (PERIODIC DISEASE).

Chemical Identity

Chemical Information

Molecular Formula
C22H25NO6
Molecular Weight
399.4 g/mol
CAS Registry No.
64-86-8
IUPAC Name
N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
InChIKey
IAKHMKGGTNLKSZ-INIZCTEOSA-N
SMILES
CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC
MeSH Unique ID
D003078
Source
PubChem CID 6167

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

See Also

MeSH Record

Synonyms

2 entry terms
  • Colchicine, (+-)-Isomer
  • Colchicine, (R)-Isomer

MeSH Record

Aspects Covered

27 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Hierarchy

Tree Number

  1. D03w.132w.225w

MeSH Record

NLM Classification

QV 98

AMA Style

References

  1. National Library of Medicine. Colchicine. Medical Subject Headings (MeSH). 2026. Unique ID D003078. http://id.nlm.nih.gov/mesh/2026/D003078
  2. Colchicine. In: Wikipedia. https://en.wikipedia.org/wiki/Colchicine
  3. Colchicine. In: Wikidata. https://www.wikidata.org/wiki/Q326224
  4. Colchicine. In: PubChem Compound. CID 6167. https://pubchem.ncbi.nlm.nih.gov/compound/6167