Chemicals and Drugs

Clobetasol

A derivative of PREDNISOLONE with high glucocorticoid activity and low mineralocorticoid activity. Absorbed through the skin faster than FLUOCINONIDE, it is used topically in treatment of PSORIASIS but may cause marked adrenocortical suppression.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A derivative of PREDNISOLONE with high glucocorticoid activity and low mineralocorticoid activity. Absorbed through the skin faster than FLUOCINONIDE, it is used topically in treatment of PSORIASIS but may cause marked adrenocortical suppression.

Chemical Identity

Chemical Information

Molecular Formula
C22H28ClFO4
Molecular Weight
410.9 g/mol
CAS Registry No.
25122-41-2
IUPAC Name
(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
InChIKey
FCSHDIVRCWTZOX-DVTGEIKXSA-N
SMILES
C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CCl)O)C)O)F)C
MeSH Unique ID
D002990
Source
PubChem CID 5311051

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

11 entry terms
  • Clofenazon
  • Clobetasol 17-Propionate
  • Clobetasol Propionate
  • Clobex
  • Cormax
  • Dermovate
  • Embeline
  • Embeline E
  • OLUX
  • Temovate
  • Clobetasol 17 Propionate

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

1991(1977); for CLOBETASOL PROPIONATE use COLBETASOL (NM) 1979

MeSH Record

Previous Indexing

  • Betamethasone (1974-1976)
  • Propionates (1974)
  • Steroids, Chlorinated (1974-1975)

MeSH Hierarchy

Tree Number

  1. D04w.210.500w.908.093w.250w

AMA Style

References

  1. National Library of Medicine. Clobetasol. Medical Subject Headings (MeSH). 2026. Unique ID D002990. http://id.nlm.nih.gov/mesh/2026/D002990
  2. Clobetasol. In: Wikipedia. https://en.wikipedia.org/wiki/Clobetasol
  3. Clobetasol. In: Wikidata. https://www.wikidata.org/wiki/Q4224007
  4. Clobetasol. In: PubChem Compound. CID 5311051. https://pubchem.ncbi.nlm.nih.gov/compound/5311051