Diseases

Chronic Granulomatous Disease

A defect of leukocyte function in which phagocytic cells ingest but fail to digest bacteria, resulting in recurring bacterial infections with granuloma formation. When chronic granulomatous disease is caused by mutations in the CYBB gene, the condition is inherited in an X-linked recessive pattern. When chronic granulomatous disease is caused by CYBA, NCF1, NCF2, or NCF4 gene mutations, the condition is inherited in an autosomal recessive pattern.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A defect of leukocyte function in which phagocytic cells ingest but fail to digest bacteria, resulting in recurring bacterial infections with granuloma formation. When chronic granulomatous disease is caused by mutations in the CYBB gene, the condition is inherited in an X-linked recessive pattern. When chronic granulomatous disease is caused by CYBA, NCF1, NCF2, or NCF4 gene mutations, the condition is inherited in an autosomal recessive pattern.

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Classification

Broader headings

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See Also

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Synonyms

13 entry terms
  • Granulomatous Disease, Chronic
  • Chronic Granulomatous Diseases
  • Granulomatous Diseases, Chronic
  • Autosomal Recessive Chronic Granulomatous Disease
  • Chronic Granulomatous Disease, Atypical
  • Chronic Granulomatous Disease, X-Linked
  • Cytochrome B-Negative Granulomatous Disease, Chronic, X-Linked
  • Cytochrome B-Positive Granulomatous Disease, Chronic, X-Linked
  • Granulomatous Disease, Chronic, X-Linked
  • Granulomatous Disease, Chronic, X-Linked, Variant
  • X-Linked Chronic Granulomatous Disease
  • Chronic Granulomatous Disease, X Linked
  • X Linked Chronic Granulomatous Disease

MeSH Record

Aspects Covered

35 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

Indexing Annotation

also called granulomatous disease of childhood

MeSH Record

History Note

78(75); was see under PHAGOCYTE BACTERICIDAL DYSFUNCTION 1972-77

MeSH Record

Previous Indexing

  • Granuloma (1966-1971)
  • Immunologic Deficiency Syndromes (1968-1971)
  • Phagocyte Bactericidal Dysfunction (1972-1977)
  • Phagocytosis (1966-1971)

MeSH Hierarchy

Tree Numbers

  1. C15.378w.553.774w.535w
  2. C16w.320w.322.233w
  3. C20w.673w.774w.535w
  4. C23.550.291.500w.423w

MeSH Record

NLM Classification

QW 740

AMA Style

References

  1. National Library of Medicine. Chronic Granulomatous Disease. Medical Subject Headings (MeSH). 2026. Unique ID D006105. http://id.nlm.nih.gov/mesh/2026/D006105
  2. Chronic Granulomatous Disease. In: Wikipedia. https://en.wikipedia.org/wiki/Chronic_granulomatous_disease
  3. Chronic Granulomatous Disease. In: Wikidata. https://www.wikidata.org/wiki/Q2165663