Structured Summary
Abstract
A membrane-bound cytochrome P450 enzyme that catalyzes the 7-alpha-hydroxylation of CHOLESTEROL in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP7, converts cholesterol to 7-alpha-hydroxycholesterol which is the first and rate-limiting step in the synthesis of BILE ACIDS.
MeSH Record
Classification
Broader headings
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MeSH Record
Synonyms
14 entry terms
- CYP 7
- CYP 7A
- CYP7
- CYP7A
- Cholesterol 7-alpha-Monooxygenase
- Cholesterol 7alpha-Hydroxylase
- Cholesterol-7-Hydroxylase
- Cytochrome P-450 CYP7
- Cytochrome P450 7
- Cholesterol 7 Hydroxylase
- Cholesterol 7 alpha Hydroxylase
- Cholesterol 7 alpha Monooxygenase
- Cholesterol 7alpha Hydroxylase
- Cytochrome P 450 CYP7
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2003 (1975)
MeSH Record
Previous Indexing
- Cholesterol (1974)
- Steroid Hydroxylases (1974)
MeSH Hierarchy
Tree Numbers
MeSH Record
NLM Classification
QU 140
AMA Style
References
- National Library of Medicine. Cholesterol 7-alpha-Hydroxylase. Medical Subject Headings (MeSH). 2026. Unique ID D002790. http://id.nlm.nih.gov/mesh/2026/D002790
- Cholesterol 7-alpha-Hydroxylase. In: Wikidata. https://www.wikidata.org/wiki/Q5104318