Phenomena and Processes

Central Tolerance

The mechanism, in central lymphoid organs (THYMUS; BONE MARROW), that prevents immature lymphocytes from reacting to SELF-ANTIGENS. This is accomplished by CLONAL ANERGY and CLONAL DELETION.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The mechanism, in central lymphoid organs (THYMUS; BONE MARROW), that prevents immature lymphocytes from reacting to SELF-ANTIGENS. This is accomplished by CLONAL ANERGY and CLONAL DELETION.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

1 entry terms
  • Tolerance, Central

MeSH Record

Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

2012

MeSH Record

Previous Indexing

  • Immune Tolerance (1980-2011)
  • Self Tolerance (1998-2011)

MeSH Hierarchy

Tree Number

  1. G12.535w.425w.800.200w

AMA Style

References

  1. National Library of Medicine. Central Tolerance. Medical Subject Headings (MeSH). 2026. Unique ID D061167. http://id.nlm.nih.gov/mesh/2026/D061167
  2. Central Tolerance. In: Wikipedia. https://en.wikipedia.org/wiki/Central_tolerance
  3. Central Tolerance. In: Wikidata. https://www.wikidata.org/wiki/Q606766