Chemicals and Drugs

BRCA1 Protein

The phosphoprotein encoded by the BRCA1 gene (GENE, BRCA1). It contains an N-terminal RING FINGER DOMAIN and is a PROTEIN PHOSPHATASE 1 regulatory subunit. In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (Science 1995;270(5237):713,789-91)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The phosphoprotein encoded by the BRCA1 gene (GENE, BRCA1). It contains an N-terminal RING FINGER DOMAIN and is a PROTEIN PHOSPHATASE 1 regulatory subunit. In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (Science 1995;270(5237):713,789-91)

MeSH Record

Classification

Broader headings

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See Also

MeSH Record

Synonyms

5 entry terms
  • BRCA1 Gene Product
  • Breast Cancer 1 Gene Product
  • Breast Cancer 1 Protein
  • Breast Cancer Type 1 Susceptibility Protein
  • Ring Finger Protein 53

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

97; was BRCA1 PROTEIN (NM) 1994-96

MeSH Record

Previous Indexing

  • Neoplasm Proteins (1994-1996)
  • Transcription Factors (1994-1996)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.313.125w
  2. D12.776w.624.776.100w
  3. D12.776w.660w.100w
  4. D12.776w.744w.100w
  5. D12.776w.930w.137w

MeSH Record

NLM Classification

WP 870

AMA Style

References

  1. National Library of Medicine. BRCA1 Protein. Medical Subject Headings (MeSH). 2026. Unique ID D019313. http://id.nlm.nih.gov/mesh/2026/D019313
  2. BRCA1 Protein. In: Wikipedia. https://en.wikipedia.org/wiki/BRCA1
  3. BRCA1 Protein. In: Wikidata. https://www.wikidata.org/wiki/Q17487737