Structured Summary
Abstract
A costimulatory ligand membrane glycoprotein that contains a V2 type and C2 IMMUNOGLOBULIN DOMAIN and is expressed by ANTIGEN-PRESENTING CELLS. It binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
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Synonyms
14 entry terms
- Antigen, B7-1
- Antigens, CD80
- B-Cell Activation Antigen
- B7-1 Costimulatory Molecule
- B7-1 Ligand
- CD80 Antigen
- CD80 Antigens
- Antigen, B7 1
- B Cell Activation Antigen
- B7 1 Antigen
- B7 1 Costimulatory Molecule
- B7 1 Ligand
- Costimulatory Molecule, B7-1
- Ligand, B7-1
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Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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History Note
2018 (1991)
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Previous Indexing
- Antigens, Surface (1991-1993)
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AMA Style
References
- National Library of Medicine. B7-1 Antigen. Medical Subject Headings (MeSH). 2026. Unique ID D018122. http://id.nlm.nih.gov/mesh/2026/D018122
- B7-1 Antigen. In: Wikipedia. https://en.wikipedia.org/wiki/CD80
- B7-1 Antigen. In: Wikidata. https://www.wikidata.org/wiki/Q5009843