Structured Summary
Abstract
An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.
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Classification
Broader headings
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Synonyms
13 entry terms
- Androstenedione Aromatase
- CYP 19
- CYP19
- CYP19 Protein
- Cytochrome P-450 CYP19
- Cytochrome P-450(AROM)
- Cytochrome P450 19
- Estrogen Synthase
- Estrogen Synthetase
- P450AROM
- Aromatase, Androstenedione
- Cytochrome P 450 CYP19
- Protein, CYP19
MeSH Record
Aspects Covered
28 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
86(75); was see under OXIDOREDUCTASES 1975-85
MeSH Record
Previous Indexing
- Androstanes (1972-1974)
- Estrogens (1972-1974)
- Oxidoreductases (1972-1974)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Aromatase. Medical Subject Headings (MeSH). 2026. Unique ID D001141. http://id.nlm.nih.gov/mesh/2026/D001141
- Aromatase. In: Wikidata. https://www.wikidata.org/wiki/Q21149532