Chemicals and Drugs

Aripiprazole

A piperazine and quinolone derivative that is used primarily as an antipsychotic agent. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS, where it also functions as a post-synaptic antagonist, and an antagonist of SEROTONIN RECEPTOR, 5-HT2A. It is used for the treatment of SCHIZOPHRENIA and BIPOLAR DISORDER, and as an adjunct therapy for the treatment of depression.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A piperazine and quinolone derivative that is used primarily as an antipsychotic agent. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS, where it also functions as a post-synaptic antagonist, and an antagonist of SEROTONIN RECEPTOR, 5-HT2A. It is used for the treatment of SCHIZOPHRENIA and BIPOLAR DISORDER, and as an adjunct therapy for the treatment of depression.

Chemical Identity

Chemical Information

Molecular Formula
C23H27Cl2N3O2
Molecular Weight
448.4 g/mol
CAS Registry No.
129722-12-9
IUPAC Name
7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one
InChIKey
CEUORZQYGODEFX-UHFFFAOYSA-N
SMILES
C1CC(=O)NC2=C1C=CC(=C2)OCCCCN3CCN(CC3)C4=C(C(=CC=C4)Cl)Cl
MeSH Unique ID
D000068180
Source
PubChem CID 60795

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

5 entry terms
  • 7-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butyloxy)-3,4-dihydro-2(1H)-quinolinone
  • Aripiprazol
  • Abilify
  • OPC 14597
  • OPC-14597

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2016 (1995)

MeSH Hierarchy

Tree Numbers

  1. D03w.383.606w.170w
  2. D03w.633.100.810.835.122w

AMA Style

References

  1. National Library of Medicine. Aripiprazole. Medical Subject Headings (MeSH). 2026. Unique ID D000068180. http://id.nlm.nih.gov/mesh/2026/D000068180
  2. Aripiprazole. In: Wikipedia. https://en.wikipedia.org/wiki/Aripiprazole
  3. Aripiprazole. In: Wikidata. https://www.wikidata.org/wiki/Q411188
  4. Aripiprazole. In: PubChem Compound. CID 60795. https://pubchem.ncbi.nlm.nih.gov/compound/60795