Structured Summary
Abstract
An enzyme that catalyzes the oxidation of arachidonic acid to yield 12-hydroperoxyarachidonate (12-HPETE) which is itself rapidly converted by a peroxidase to 12-hydroxy-5,8,10,14-eicosatetraenoate (12-HETE). The 12-hydroperoxides are preferentially formed in PLATELETS.
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Classification
Broader headings
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MeSH Record
Synonyms
7 entry terms
- 12-Lipoxygenase
- Arachidonic Acid 12-Lipoxygenase
- 12 Lipoxygenase
- 12-Lipoxygenase, Arachidonate
- 12-Lipoxygenase, Arachidonic Acid
- Arachidonate 12 Lipoxygenase
- Arachidonic Acid 12 Lipoxygenase
MeSH Record
Aspects Covered
28 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
91(87); was see under ARACHIDONATE LIPOXYGENASES 1987-90
MeSH Record
Previous Indexing
- Lipoxygenases (1974-1986)
- Oxygenases (1966-1973)
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AMA Style
References
- National Library of Medicine. Arachidonate 12-Lipoxygenase. Medical Subject Headings (MeSH). 2026. Unique ID D001092. http://id.nlm.nih.gov/mesh/2026/D001092
- Arachidonate 12-Lipoxygenase. In: Wikipedia. https://en.wikipedia.org/wiki/Arachidonate_12-lipoxygenase
- Arachidonate 12-Lipoxygenase. In: Wikidata. https://www.wikidata.org/wiki/Q3621198