Chemicals and Drugs

Angiopoietin-Like Protein 4

A secreted angiopoietin-like protein expressed under hypoxic conditions by ENDOTHELIAL CELLS. It inhibits cell proliferation, cell migration, and tubule formation; the inactive form accumulates in the endothelial EXTRACELLULAR MATRIX, reducing vascular leakage. ANGPTL4 has direct roles in regulating glucose and lipid metabolism, as well as INSULIN SENSITIVITY, and may also function as a regulator of angiogenesis and tumorigenesis.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A secreted angiopoietin-like protein expressed under hypoxic conditions by ENDOTHELIAL CELLS. It inhibits cell proliferation, cell migration, and tubule formation; the inactive form accumulates in the endothelial EXTRACELLULAR MATRIX, reducing vascular leakage. ANGPTL4 has direct roles in regulating glucose and lipid metabolism, as well as INSULIN SENSITIVITY, and may also function as a regulator of angiogenesis and tumorigenesis.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

6 entry terms
  • ANGPTL4 Protein
  • Angiopoietin-related Protein 4
  • 4, Angiopoietin-Like Protein
  • Angiopoietin Like Protein 4
  • Angiopoietin related Protein 4
  • Protein 4, Angiopoietin-Like

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2022(2018)

MeSH Record

Previous Indexing

  • Angiopoietins (2004-2017)
  • Blood Proteins (2000-2017)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.276.100.050w.400
  2. D12.776w.467.100.050w.400
  3. D23.529.100.050w.400

AMA Style

References

  1. National Library of Medicine. Angiopoietin-Like Protein 4. Medical Subject Headings (MeSH). 2026. Unique ID D000075803. http://id.nlm.nih.gov/mesh/2026/D000075803
  2. Angiopoietin-Like Protein 4. In: Wikidata. https://www.wikidata.org/wiki/Q24774823