Chemicals and Drugs

Aconitine

A C19 norditerpenoid alkaloid (DITERPENES) from the root of ACONITUM; DELPHINIUM and larkspurs. It activates VOLTAGE-GATED SODIUM CHANNELS. It has been used to induce ARRHYTHMIAS in experimental animals and it has anti-inflammatory and anti-neuralgic properties.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A C19 norditerpenoid alkaloid (DITERPENES) from the root of ACONITUM; DELPHINIUM and larkspurs. It activates VOLTAGE-GATED SODIUM CHANNELS. It has been used to induce ARRHYTHMIAS in experimental animals and it has anti-inflammatory and anti-neuralgic properties.

Chemical Identity

Chemical Information

Molecular Formula
C34H47NO11
Molecular Weight
645.7 g/mol
CAS Registry No.
302-27-2
IUPAC Name
[(1S,2R,3R,4R,5R,6S,7S,8R,9R,13R,14R,16S,17S,18R)-8-acetyloxy-11-ethyl-5,7,14-trihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-4-yl] benzoate
InChIKey
XFSBVAOIAHNAPC-XTHSEXKGSA-N
SMILES
CCN1C[C@@]2([C@@H](C[C@@H]([C@@]34[C@@H]2[C@H]([C@@H](C31)[C@@]5([C@@H]6[C@H]4C[C@@]([C@@H]6OC(=O)C7=CC=CC=C7)([C@H]([C@@H]5O)OC)O)OC(=O)C)OC)OC)O)COC
MeSH Unique ID
D000157
Source
PubChem CID 245005

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

4 entry terms
  • Acetylbenzoyl-aconine
  • Acetylbenzoylaconine
  • Aconitane-3,8,13,14,15-pentol, 20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, 8-acetate 14-benzoate, (1alpha,3alpha,6alpha,14alpha,15alpha,16beta)-
  • Acetylbenzoyl aconine

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

ACONITE (see ACONITUM) is also available

MeSH Record

History Note

91(75); was see under ACONITE 1975-90

MeSH Record

Previous Indexing

  • Aconite (1972-1974)

MeSH Hierarchy

Tree Numbers

  1. D02w.455w.849w.291w.184w.037w
  2. D03w.132w.301w.030w

AMA Style

References

  1. National Library of Medicine. Aconitine. Medical Subject Headings (MeSH). 2026. Unique ID D000157. http://id.nlm.nih.gov/mesh/2026/D000157
  2. Aconitine. In: Wikipedia. https://en.wikipedia.org/wiki/Aconitine
  3. Aconitine. In: Wikidata. https://www.wikidata.org/wiki/Q342108
  4. Aconitine. In: PubChem Compound. CID 245005. https://pubchem.ncbi.nlm.nih.gov/compound/245005