Chemicals and Drugs

Abnormal Fibrinogens

Fibrinogens which have a functional defect as the result of one or more amino acid substitutions in the amino acid sequence of normal fibrinogen. Abnormalities of the fibrinogen molecule may impair any of the major steps involved in the conversion of fibrinogen into stabilized fibrin, such as cleavage of the fibrinopeptides by thrombin, polymerization and cross-linking of fibrin. The resulting dysfibrinogenemias can be clinically silent or can be associated with bleeding, thrombosis or defective wound healing.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Fibrinogens which have a functional defect as the result of one or more amino acid substitutions in the amino acid sequence of normal fibrinogen. Abnormalities of the fibrinogen molecule may impair any of the major steps involved in the conversion of fibrinogen into stabilized fibrin, such as cleavage of the fibrinopeptides by thrombin, polymerization and cross-linking of fibrin. The resulting dysfibrinogenemias can be clinically silent or can be associated with bleeding, thrombosis or defective wound healing.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

1 entry terms
  • Fibrinogens, Abnormal

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

89

MeSH Record

Previous Indexing

  • Fibrinogen (1966-1988)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.124w.050w.250w.265
  2. D12.776w.124w.125.500w.265
  3. D23.119.490w.265

AMA Style

References

  1. National Library of Medicine. Abnormal Fibrinogens. Medical Subject Headings (MeSH). 2026. Unique ID D015241. http://id.nlm.nih.gov/mesh/2026/D015241
  2. Abnormal Fibrinogens. In: Wikidata. https://www.wikidata.org/wiki/Q76524549