Structured Summary
Abstract
An APOBEC deaminase that functions as an inhibitor of RETROVIRIDAE replication and inhibits the mobility of RETROTRANSPOSONS via deaminase-dependent and independent mechanisms. It is selective for SINGLE-STRANDED DNA and does not deaminate double-stranded DNA or single or DOUBLE-STRANDED RNA. It exhibits potent antiviral activity against VIF PROTEIN deficient HIV-1 through the creation of hypermutations in the VIRAL DNA. It also has anti-viral activity against SIMIAN IMMUNODEFICIENCY VIRUSES and HEPATITIS B VIRUS.
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Classification
Broader headings
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MeSH Record
Synonyms
15 entry terms
- APOBEC-3G Protein
- APOBEC-3G dC-dU Editing Enzyme
- APOBEC-Related Cytidine Deaminase
- APOBEC-Related Protein
- APOBEC3G Deaminase
- APOBEC3G Protein
- CEM15 Protein
- APOBEC 3G Deaminase
- APOBEC 3G Protein
- APOBEC 3G dC dU Editing Enzyme
- APOBEC Related Cytidine Deaminase
- APOBEC Related Protein
- Cytidine Deaminase, APOBEC-Related
- Deaminase, APOBEC-3G
- Deaminase, APOBEC3G
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2017
MeSH Record
Previous Indexing
- Cytidine Deaminase (2007-2016)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. APOBEC-3G Deaminase. Medical Subject Headings (MeSH). 2026. Unique ID D000071480. http://id.nlm.nih.gov/mesh/2026/D000071480
- APOBEC-3G Deaminase. In: Wikidata. https://www.wikidata.org/wiki/Q296209