Chemicals and Drugs

ADAMTS5 Protein

An ADAMTS protease that contains two C-terminal thrombospondin (TS) motifs. It functions primarily as an aggrecanase, cleaving AGGRECAN in CARTILAGE, and may be involved in the destruction of aggrecan in ARTHRITIS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An ADAMTS protease that contains two C-terminal thrombospondin (TS) motifs. It functions primarily as an aggrecanase, cleaving AGGRECAN in CARTILAGE, and may be involved in the destruction of aggrecan in ARTHRITIS.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

7 entry terms
  • A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5 Protein
  • ADAMTS-5 Protein
  • ADAMTS11 Protein
  • ADAMTS5 Protease
  • Aggrecanase-2
  • ADAMTS 5 Protein
  • Aggrecanase 2

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017

MeSH Record

Previous Indexing

  • ADAM Proteins (2006-2016)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.656w.675w.374w.102w.500w.875
  2. D09w.400w.430w.500w.500w.875
  3. D12.776w.395w.033w.500w.875
  4. D12.776w.860w.300.085w.875

AMA Style

References

  1. National Library of Medicine. ADAMTS5 Protein. Medical Subject Headings (MeSH). 2026. Unique ID D000071116. http://id.nlm.nih.gov/mesh/2026/D000071116
  2. ADAMTS5 Protein. In: Wikidata. https://www.wikidata.org/wiki/Q24784926