Chemicals and Drugs

ADAMTS4 Protein

An ADAMTS protease similar to ADAMTS5 PROTEIN. It contains a single C-terminal thrombospondin (TS) motif and cleaves AGGRECAN in CARTILAGE. It may also be involved in the destruction of aggrecan in ARTHRITIS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An ADAMTS protease similar to ADAMTS5 PROTEIN. It contains a single C-terminal thrombospondin (TS) motif and cleaves AGGRECAN in CARTILAGE. It may also be involved in the destruction of aggrecan in ARTHRITIS.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

5 entry terms
  • A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4 Protein
  • ADAMTS-4 Protein
  • Aggrecanase-1
  • ADAMTS 4 Protein
  • Aggrecanase 1

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017 (1999)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.656w.675w.374w.102w.500w.844w
  2. D09w.400w.430w.500w.500w.844w
  3. D12.776w.395w.033w.500w.844w
  4. D12.776w.860w.300.085w.844w

AMA Style

References

  1. National Library of Medicine. ADAMTS4 Protein. Medical Subject Headings (MeSH). 2026. Unique ID D000071121. http://id.nlm.nih.gov/mesh/2026/D000071121
  2. ADAMTS4 Protein. In: Wikipedia. https://en.wikipedia.org/wiki/ADAMTS-4_endopeptidase
  3. ADAMTS4 Protein. In: Wikidata. https://www.wikidata.org/wiki/Q13107617