Structured Summary
Abstract
An ADAMTS protease that contains eight thrombospondin (TS) motifs. It cleaves VON WILLEBRAND FACTOR to control vWF-mediated THROMBOSIS. Mutations in the ADAMTS13 gene have been identified in familial cases of PURPURA, THROMBOTIC THROMBOCYTOPENIC and defects in ADAMTS13 activity are associated with MYOCARDIAL INFARCTION; BRAIN ISCHEMIA; PRE-ECLAMPSIA; and MALARIA.
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Broader headings
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Synonyms
8 entry terms
- A Disintegrin and Metalloproteinase with Thrombospondin Motifs 13 Protein
- ADAMTS-13 Protein
- ADAMTS13 Protease
- vWF-Cleaving Protease
- von Willebrand Factor-Cleaving Protease
- ADAMTS 13 Protein
- vWF Cleaving Protease
- von Willebrand Factor Cleaving Protease
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2017
MeSH Record
Previous Indexing
- ADAM Proteins (2006-2016)
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AMA Style
References
- National Library of Medicine. ADAMTS13 Protein. Medical Subject Headings (MeSH). 2026. Unique ID D000071120. http://id.nlm.nih.gov/mesh/2026/D000071120
- ADAMTS13 Protein. In: Wikidata. https://www.wikidata.org/wiki/Q4651006