Chemicals and Drugs

25-Hydroxyvitamin D3 1-alpha-Hydroxylase

A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

19 entry terms
  • 25-Hydroxycholecalciferol 1-Hydroxylase
  • 25-Hydroxycholecalciferol-1-Hydroxylase
  • 25-Hydroxyergocalciferol 1-alpha-Hydroxylase
  • 25-Hydroxyvitamin D 1-alpha-Hydroxylase
  • 25-Hydroxyvitamin D(3) 1 alpha-Hydroxylase
  • 25-Hydroxyvitamin D2 1-hydroxylase
  • CYP27B1
  • Calcidiol 1-Monooxygenase
  • Cytochrome P-450 CYP27B1
  • 1-alpha-Hydroxylase, 25-Hydroxyergocalciferol
  • 1-alpha-Hydroxylase, 25-Hydroxyvitamin D
  • 1-hydroxylase, 25-Hydroxyvitamin D2
  • 25 Hydroxycholecalciferol 1 Hydroxylase
  • 25 Hydroxyergocalciferol 1 alpha Hydroxylase
  • 25 Hydroxyvitamin D 1 alpha Hydroxylase
  • 25 Hydroxyvitamin D2 1 hydroxylase
  • 25 Hydroxyvitamin D3 1 alpha Hydroxylase
  • Calcidiol 1 Monooxygenase
  • Cytochrome P 450 CYP27B1

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2003 (1975); for 25-HYDROXYVITAMIN D2 1-HYDROXYLASE use STEROID HYDROXYLASES (NM) 1976-2002

MeSH Record

Previous Indexing

  • Hydroxycholecalciferols (1973-1974)
  • Steroid Hydroxylases (1973-1974)

MeSH Hierarchy

Tree Numbers

  1. D08.244w.453w.499.500w
  2. D08.244w.453w.915w.400w
  3. D08.811w.682w.690w.708.170w.493.500w
  4. D08.811w.682w.690w.708.170w.915w.400w
  5. D12.776w.422w.220w.453w.499.500w
  6. D12.776w.422w.220w.453w.915w.400w

AMA Style

References

  1. National Library of Medicine. 25-Hydroxyvitamin D3 1-alpha-Hydroxylase. Medical Subject Headings (MeSH). 2026. Unique ID D015090. http://id.nlm.nih.gov/mesh/2026/D015090
  2. 25-Hydroxyvitamin D3 1-alpha-Hydroxylase. In: Wikipedia. https://en.wikipedia.org/wiki/25-Hydroxyvitamin_D_1-alpha-hydroxylase
  3. 25-Hydroxyvitamin D3 1-alpha-Hydroxylase. In: Wikidata. https://www.wikidata.org/wiki/Q1149122