Chemicals and Drugs

tat Gene Products

Trans-acting transcription factors produced by retroviruses such as HIV. They are nuclear proteins whose expression is required for viral replication. The tat protein stimulates LONG TERMINAL REPEAT-driven RNA synthesis for both viral regulatory and viral structural proteins. Tat stands for trans-activation of transcription.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Trans-acting transcription factors produced by retroviruses such as HIV. They are nuclear proteins whose expression is required for viral replication. The tat protein stimulates LONG TERMINAL REPEAT-driven RNA synthesis for both viral regulatory and viral structural proteins. Tat stands for trans-activation of transcription.

MeSH Record

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Synonyms

4 entry terms
  • Gene Product, tat
  • Gene Products, tat
  • tat Protein
  • tat Gene Product

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

91(90); was see under TRANS-ACTIVATORS 1990

MeSH Record

Previous Indexing

  • Transcription Factors (1988-1989)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.260w.755.199
  2. D12.776w.930w.900.199
  3. D12.776w.964w.900w.750.750
  4. D12.776w.964w.925w.984.400

AMA Style

References

  1. National Library of Medicine. tat Gene Products. Medical Subject Headings (MeSH). 2026. Unique ID D015696. http://id.nlm.nih.gov/mesh/2026/D015696
  2. tat Gene Products. In: Wikidata. https://www.wikidata.org/wiki/Q67206347