Chemicals and Drugs

p21-Activated Kinases

A family of serine-threonine kinases that bind to and are activated by MONOMERIC GTP-BINDING PROTEINS such as RAC GTP-BINDING PROTEINS and CDC42 GTP-BINDING PROTEIN. They are intracellular signaling kinases that play a role the regulation of cytoskeletal organization.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A family of serine-threonine kinases that bind to and are activated by MONOMERIC GTP-BINDING PROTEINS such as RAC GTP-BINDING PROTEINS and CDC42 GTP-BINDING PROTEIN. They are intracellular signaling kinases that play a role the regulation of cytoskeletal organization.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

40 entry terms
  • PAK Kinase
  • PAK Kinases
  • p21-Activated Kinase
  • Kinase, PAK
  • Kinase, p21-Activated
  • Kinases, PAK
  • Kinases, p21-Activated
  • p21 Activated Kinase
  • p21 Activated Kinases
  • Oligophrenin-3
  • PAK-1 Kinase
  • PAK-2 Kinase
  • PAK1 Kinase
  • PAK2 Kinase
  • PAK3 Kinase
  • PAK65
  • Serine-Threonine-Protein Kinase PAK 1
  • Serine-Threonine-Protein Kinase PAK 3
  • alpha p21-Activated Kinase
  • alpha-PAK
  • beta p21-Activated Kinase
  • beta-PAK
  • gamma-PAK
  • p21-Activated Kinase 1
  • p21-Activated Kinase 2
  • p21-Activated Kinase 3
  • p65(PAK)
  • p65PAK Protein
  • Oligophrenin 3
  • PAK 1 Kinase
  • PAK 2 Kinase
  • Serine Threonine Protein Kinase PAK 1
  • Serine Threonine Protein Kinase PAK 3
  • alpha p21 Activated Kinase
  • beta p21 Activated Kinase
  • gamma PAK
  • p21 Activated Kinase 1
  • p21 Activated Kinase 2
  • p21 Activated Kinase 3
  • p21-Activated Kinase, beta

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2008

MeSH Record

Previous Indexing

  • Protein-Serine-Threonine Kinases (1995-2007)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.700w.596w
  2. D12.776w.476.563w.596w

AMA Style

References

  1. National Library of Medicine. p21-Activated Kinases. Medical Subject Headings (MeSH). 2026. Unique ID D054462. http://id.nlm.nih.gov/mesh/2026/D054462
  2. p21-Activated Kinases. In: Wikipedia. https://en.wikipedia.org/wiki/P21-activated_kinases
  3. p21-Activated Kinases. In: Wikidata. https://www.wikidata.org/wiki/Q7117843