Structured Summary
Abstract
A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis.
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Broader headings
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MeSH Record
Synonyms
66 entry terms
- DAI Protein Kinase
- DSRNA-Dep Protein Kinase
- Double Stranded RNA-Dependent Kinase (dsl)
- Double Stranded RNA-Dependent eIF-2 alpha Protein Kinase
- Eukaryotic Initiation Factor 2alpha Kinase
- Heme Controlled Repressor
- Heme-Controlled Inhibitor
- Heme-Controlled Translational Repressor
- Heme-Regulated eIF-2alpha Kinase
- Hemin Controlled Repressor
- Hemin-Controlled Translational Repressor
- P68 Protein Kinase
- Protein Kinase PKR
- Protein Kinase, RNA Activated
- RNA-Dependent Protein Kinase
- Self-Phosphorylating Protein Kinase
- TIK Kinase
- dsRNA-Activated Inhibitor
- eIF-2alpha Kinase
- eRF, eIF-2 Recycling Factor
- p65 Kinase
- p68 Kinase
- Controlled Repressor, Heme
- Controlled Repressor, Hemin
- DSRNA Dep Protein Kinase
- Double Stranded RNA Dependent eIF 2 alpha Protein Kinase
- Heme Controlled Inhibitor
- Heme Controlled Translational Repressor
- Heme Regulated eIF 2alpha Kinase
- Hemin Controlled Translational Repressor
- Inhibitor, Heme-Controlled
- Inhibitor, dsRNA-Activated
- Kinase PKR, Protein
- Kinase, DAI Protein
- Kinase, DSRNA-Dep Protein
- Kinase, Heme-Regulated eIF-2alpha
- Kinase, P68 Protein
- Kinase, RNA-Dependent Protein
- Kinase, Self-Phosphorylating Protein
- Kinase, TIK
- Kinase, eIF-2
- Kinase, eIF-2alpha
- Kinase, p65
- Kinase, p68
- PKR, Protein Kinase
- Protein Kinase, DAI
- Protein Kinase, DSRNA-Dep
- Protein Kinase, P68
- Protein Kinase, RNA-Dependent
- Protein Kinase, Self-Phosphorylating
- RNA Dependent Protein Kinase
- Repressor, Heme Controlled
- Repressor, Heme-Controlled Translational
- Repressor, Hemin Controlled
- Repressor, Hemin-Controlled Translational
- Self Phosphorylating Protein Kinase
- Translational Repressor, Heme-Controlled
- Translational Repressor, Hemin-Controlled
- dsRNA Activated Inhibitor
- eIF 2 Kinase
- eIF 2alpha Kinase
- eIF-2alpha Kinase, Heme-Regulated
- eRF, eIF 2 Recycling Factor
- PERK Kinase
- PKR-like ER Protein Kinase
- PRK-like ER Kinase
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
98; use EIF-2 KINASE (NM) 1980-97
MeSH Record
Previous Indexing
- Protein Kinases (1980-1993)
- Protein-Serine-Threonine Kinases (1993-1997)
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AMA Style
References
- National Library of Medicine. eIF-2 Kinase. Medical Subject Headings (MeSH). 2026. Unique ID D019892. http://id.nlm.nih.gov/mesh/2026/D019892
- eIF-2 Kinase. In: Wikipedia. https://en.wikipedia.org/wiki/EIF-2_kinase
- eIF-2 Kinase. In: Wikidata. https://www.wikidata.org/wiki/Q5323131