Structured Summary
Abstract
A receptor tyrosine kinase that transduces signals from EXTRACELLULAR MATRIX to the CYTOPLASM by binding ligands such as GALECTIN 3. It regulates many physiologic processes that include cell survival, migration, differentiation, and PHAGOCYTOSIS of apoptotic cells and ROD PHOTORECEPTORS in the RETINAL PIGMENT EPITHELIUM. Mutations in the MERTK gene are associated with type 38 RETINITIS PIGMENTOSA; it also plays a critical role as an inhibitor of TOLL-LIKE RECEPTORS signaling.
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Classification
Broader headings
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MeSH Record
Synonyms
6 entry terms
- MERTK
- c-Mer Proto-Oncogene Tyrosine Kinase
- Kinase, c-Mer Tyrosine
- Tyrosine Kinase, c-Mer
- c Mer Proto Oncogene Tyrosine Kinase
- c Mer Tyrosine Kinase
MeSH Record
Aspects Covered
19 allowable subheadings
Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.
MeSH Record
History Note
2018
MeSH Record
Previous Indexing
- Proto-Oncogene Proteins (1999-2017)
- Receptor Protein-Tyrosine Kinases (1999-2017)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. c-Mer Tyrosine Kinase. Medical Subject Headings (MeSH). 2026. Unique ID D000076202. http://id.nlm.nih.gov/mesh/2026/D000076202
- c-Mer Tyrosine Kinase. In: Wikidata. https://www.wikidata.org/wiki/Q21120828