Chemicals and Drugs

alpha-Mannosidase

An enzyme that catalyzes the HYDROLYSIS of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. The enzyme plays a role in the processing of newly formed N-glycans and in degradation of mature GLYCOPROTEINS. There are multiple isoforms of alpha-mannosidase, each having its own specific cellular location and pH optimum. Defects in the lysosomal form of the enzyme results in a buildup of mannoside intermediate metabolites and the disease ALPHA-MANNOSIDOSIS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An enzyme that catalyzes the HYDROLYSIS of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. The enzyme plays a role in the processing of newly formed N-glycans and in degradation of mature GLYCOPROTEINS. There are multiple isoforms of alpha-mannosidase, each having its own specific cellular location and pH optimum. Defects in the lysosomal form of the enzyme results in a buildup of mannoside intermediate metabolites and the disease ALPHA-MANNOSIDOSIS.

MeSH Record

Classification

Broader headings

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See Also

MeSH Record

Synonyms

15 entry terms
  • Neutral alpha-Mannosidase
  • alpha-D-Mannosidase
  • alpha-D-Mannoside Mannohydrolase
  • Mannohydrolase, alpha-D-Mannoside
  • Neutral alpha Mannosidase
  • alpha D Mannosidase
  • alpha D Mannoside Mannohydrolase
  • alpha Mannosidase
  • alpha-Mannosidase, Neutral
  • LAMAN
  • Lysosomal alpha-Mannosidase
  • alpha Mannosidase B
  • Lysosomal alpha Mannosidase
  • Mannosidase B, alpha
  • alpha-Mannosidase, Lysosomal

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

/DEFIC: consider also ALPHA-MANNOSIDOSIS

MeSH Record

History Note

2004; use ALPHA-MANNOSIDASE (NM) 1980-2003

MeSH Record

Previous Indexing

  • Mannosidases (1980-2003)

MeSH Hierarchy

Tree Number

  1. D08.811w.277w.450w.625w.500w

AMA Style

References

  1. National Library of Medicine. alpha-Mannosidase. Medical Subject Headings (MeSH). 2026. Unique ID D043323. http://id.nlm.nih.gov/mesh/2026/D043323
  2. alpha-Mannosidase. In: Wikipedia. https://en.wikipedia.org/wiki/%CE%91-Mannosidase
  3. alpha-Mannosidase. In: Wikidata. https://www.wikidata.org/wiki/Q4734907