Chemicals and Drugs

alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid

An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.

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Classification

Broader headings

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Drug Class

Pharmacological Action

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Synonyms

7 entry terms
  • AMPA
  • alpha Amino 3 hydroxy 5 methyl 4 isoxazolepropionic Acid
  • AMPA, (+-)-Isomer
  • AMPA, (R)-Isomer
  • AMPA, (R)-Isomer, Monohydrobromide
  • AMPA, (S)-Isomer
  • AMPA, (S)-Isomer, Monohydrobromide

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

94; was ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID (NM) 1980-93

MeSH Record

Previous Indexing

  • Ibotenic Acid/analogs & derivatives (1980-1993)

MeSH Hierarchy

Tree Number

AMA Style

References

  1. National Library of Medicine. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid. Medical Subject Headings (MeSH). 2026. Unique ID D018350. http://id.nlm.nih.gov/mesh/2026/D018350
  2. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid. In: Wikidata. https://www.wikidata.org/wiki/Q917803