/*! tailwindcss v4.3.1 | MIT License | https://tailwindcss.com */
@layer properties{@supports (((-webkit-hyphens:none)) and (not (margin-trim:inline))) or ((-moz-orient:inline) and (not (color:rgb(from red r g b)))){*,:before,:after{--tw-rotate-x:initial;--tw-rotate-y:initial;--tw-rotate-z:initial;--tw-skew-x:initial;--tw-skew-y:initial;--tw-border-style:solid;--tw-leading:initial;--tw-font-weight:initial;--tw-tracking:initial;--tw-outline-style:solid;--tw-blur:initial;--tw-brightness:initial;--tw-contrast:initial;--tw-grayscale:initial;--tw-hue-rotate:initial;--tw-invert:initial;--tw-opacity:initial;--tw-saturate:initial;--tw-sepia:initial;--tw-drop-shadow:initial;--tw-drop-shadow-color:initial;--tw-drop-shadow-alpha:100%;--tw-drop-shadow-size:initial;--tw-backdrop-blur:initial;--tw-backdrop-brightness:initial;--tw-backdrop-contrast:initial;--tw-backdrop-grayscale:initial;--tw-backdrop-hue-rotate:initial;--tw-backdrop-invert:initial;--tw-backdrop-opacity:initial;--tw-backdrop-saturate:initial;--tw-backdrop-sepia:initial}::backdrop{--tw-rotate-x:initial;--tw-rotate-y:initial;--tw-rotate-z:initial;--tw-skew-x:initial;--tw-skew-y:initial;--tw-border-style:solid;--tw-leading:initial;--tw-font-weight:initial;--tw-tracking:initial;--tw-outline-style:solid;--tw-blur:initial;--tw-brightness:initial;--tw-contrast:initial;--tw-grayscale:initial;--tw-hue-rotate:initial;--tw-invert:initial;--tw-opacity:initial;--tw-saturate:initial;--tw-sepia:initial;--tw-drop-shadow:initial;--tw-drop-shadow-color:initial;--tw-drop-shadow-alpha:100%;--tw-drop-shadow-size:initial;--tw-backdrop-blur:initial;--tw-backdrop-brightness:initial;--tw-backdrop-contrast:initial;--tw-backdrop-grayscale:initial;--tw-backdrop-hue-rotate:initial;--tw-backdrop-invert:initial;--tw-backdrop-opacity:initial;--tw-backdrop-saturate:initial;--tw-backdrop-sepia:initial}}}@layer theme{:root,:host{--color-zinc-300:lab(84.9837% .601262 -2.17985);--color-zinc-500:lab(47.8878% 1.65477 -5.77283);--color-zinc-700:lab(26.8019% 1.35386 -4.68303);--color-zinc-800:lab(15.7305% .613749 -2.16959);--color-zinc-900:lab(8.30603% .618212 -2.16573);--color-white:#fff;--spacing:.25rem;--container-2xl:42rem;--text-sm:.875rem;--text-sm--line-height:calc(1.25 / .875);--text-4xl:2.25rem;--text-4xl--line-height:calc(2.5 / 2.25);--text-5xl:3rem;--text-5xl--line-height:1;--font-weight-bold:700;--tracking-tight:-.025em;--leading-tight:1.25;--default-font-family:var(--font-geist-sans);--default-mono-font-family:var(--font-geist-mono)}}@layer base{*,:after,:before{box-sizing:border-box;border:0 solid;margin:0;padding:0}::backdrop{box-sizing:border-box;border:0 solid;margin:0;padding:0}::file-selector-button{box-sizing:border-box;border:0 solid;margin:0;padding:0}html,:host{-webkit-text-size-adjust:100%;tab-size:4;line-height:1.5;font-family:var(--default-font-family,ui-sans-serif, system-ui, sans-serif, "Apple Color Emoji", "Segoe UI Emoji", "Segoe UI Symbol", "Noto Color Emoji");font-feature-settings:var(--default-font-feature-settings,normal);font-variation-settings:var(--default-font-variation-settings,normal);-webkit-tap-highlight-color:transparent}hr{height:0;color:inherit;border-top-width:1px}abbr:where([title]){-webkit-text-decoration:underline dotted;text-decoration:underline dotted}h1,h2,h3,h4,h5,h6{font-size:inherit;font-weight:inherit}a{color:inherit;-webkit-text-decoration:inherit;-webkit-text-decoration:inherit;-webkit-text-decoration:inherit;-webkit-text-decoration:inherit;text-decoration:inherit}b,strong{font-weight:bolder}code,kbd,samp,pre{font-family:var(--default-mono-font-family,ui-monospace, SFMono-Regular, Menlo, Monaco, Consolas, "Liberation Mono", "Courier New", monospace);font-feature-settings:var(--default-mono-font-feature-settings,normal);font-variation-settings:var(--default-mono-font-variation-settings,normal);font-size:1em}small{font-size:80%}sub,sup{vertical-align:baseline;font-size:75%;line-height:0;position:relative}sub{bottom:-.25em}sup{top:-.5em}table{text-indent:0;border-color:inherit;border-collapse:collapse}:-moz-focusring{outline:auto}progress{vertical-align:baseline}summary{display:list-item}ol,ul,menu{list-style:none}img,svg,video,canvas,audio,iframe,embed,object{vertical-align:middle;display:block}img,video{max-width:100%;height:auto}button,input,select,optgroup,textarea{font:inherit;font-feature-settings:inherit;font-variation-settings:inherit;letter-spacing:inherit;color:inherit;opacity:1;background-color:#0000;border-radius:0}::file-selector-button{font:inherit;font-feature-settings:inherit;font-variation-settings:inherit;letter-spacing:inherit;color:inherit;opacity:1;background-color:#0000;border-radius:0}:where(select:is([multiple],[size])) optgroup{font-weight:bolder}:where(select:is([multiple],[size])) optgroup option{padding-inline-start:20px}::file-selector-button{margin-inline-end:4px}::placeholder{opacity:1}@supports (not ((-webkit-appearance:-apple-pay-button))) or (contain-intrinsic-size:1px){::placeholder{color:currentColor}@supports (color:color-mix(in lab, red, red)){::placeholder{color:color-mix(in oklab, currentcolor 50%, transparent)}}}textarea{resize:vertical}::-webkit-search-decoration{-webkit-appearance:none}::-webkit-date-and-time-value{min-height:1lh;text-align:inherit}::-webkit-datetime-edit{display:inline-flex}::-webkit-datetime-edit-fields-wrapper{padding:0}::-webkit-datetime-edit{padding-block:0}::-webkit-datetime-edit-year-field{padding-block:0}::-webkit-datetime-edit-month-field{padding-block:0}::-webkit-datetime-edit-day-field{padding-block:0}::-webkit-datetime-edit-hour-field{padding-block:0}::-webkit-datetime-edit-minute-field{padding-block:0}::-webkit-datetime-edit-second-field{padding-block:0}::-webkit-datetime-edit-millisecond-field{padding-block:0}::-webkit-datetime-edit-meridiem-field{padding-block:0}::-webkit-calendar-picker-indicator{line-height:1}:-moz-ui-invalid{box-shadow:none}button,input:where([type=button],[type=reset],[type=submit]){-webkit-appearance:button;appearance:button}::file-selector-button{-webkit-appearance:button;appearance:button}::-webkit-inner-spin-button{height:auto}::-webkit-outer-spin-button{height:auto}[hidden]:where(:not([hidden=until-found])){display:none!important}}@layer components;@layer utilities{.visible{visibility:visible}.fixed{position:fixed}.static{position:static}.container{width:100%}@media (min-width:40rem){.container{max-width:40rem}}@media (min-width:48rem){.container{max-width:48rem}}@media (min-width:64rem){.container{max-width:64rem}}@media (min-width:80rem){.container{max-width:80rem}}@media (min-width:96rem){.container{max-width:96rem}}.mx-auto{margin-inline:auto}.my-8{margin-block:calc(var(--spacing) * 8)}.mt-8{margin-top:calc(var(--spacing) * 8)}.block{display:block}.flex{display:flex}.grid{display:grid}.table{display:table}.h-full{height:100%}.min-h-full{min-height:100%}.w-24{width:calc(var(--spacing) * 24)}.w-full{width:100%}.max-w-2xl{max-width:var(--container-2xl)}.flex-1{flex:1}.transform{transform:var(--tw-rotate-x,) var(--tw-rotate-y,) var(--tw-rotate-z,) var(--tw-skew-x,) var(--tw-skew-y,)}.flex-col{flex-direction:column}.flex-wrap{flex-wrap:wrap}.items-center{align-items:center}.justify-center{justify-content:center}.border{border-style:var(--tw-border-style);border-width:1px}.border-t{border-top-style:var(--tw-border-style);border-top-width:1px}.border-zinc-300{border-color:var(--color-zinc-300)}.bg-white{background-color:var(--color-white)}.px-6{padding-inline:calc(var(--spacing) * 6)}.py-24{padding-block:calc(var(--spacing) * 24)}.text-center{text-align:center}.text-justify{text-align:justify}.font-mono{font-family:var(--font-geist-mono)}.font-serif{font-family:var(--font-source-serif)}.text-4xl{font-size:var(--text-4xl);line-height:var(--tw-leading,var(--text-4xl--line-height))}.text-sm{font-size:var(--text-sm);line-height:var(--tw-leading,var(--text-sm--line-height))}.text-\[0\.85em\]{font-size:.85em}.text-\[1\.05rem\]{font-size:1.05rem}.leading-7{--tw-leading:calc(var(--spacing) * 7);line-height:calc(var(--spacing) * 7)}.leading-tight{--tw-leading:var(--leading-tight);line-height:var(--leading-tight)}.font-bold{--tw-font-weight:var(--font-weight-bold);font-weight:var(--font-weight-bold)}.tracking-tight{--tw-tracking:var(--tracking-tight);letter-spacing:var(--tracking-tight)}.text-zinc-500{color:var(--color-zinc-500)}.text-zinc-700{color:var(--color-zinc-700)}.text-zinc-800{color:var(--color-zinc-800)}.text-zinc-900{color:var(--color-zinc-900)}.lowercase{text-transform:lowercase}.uppercase{text-transform:uppercase}.antialiased{-webkit-font-smoothing:antialiased;-moz-osx-font-smoothing:grayscale}.outline{outline-style:var(--tw-outline-style);outline-width:1px}.invert{--tw-invert:invert(100%);filter:var(--tw-blur,) var(--tw-brightness,) var(--tw-contrast,) var(--tw-grayscale,) var(--tw-hue-rotate,) var(--tw-invert,) var(--tw-saturate,) var(--tw-sepia,) var(--tw-drop-shadow,)}.filter{filter:var(--tw-blur,) var(--tw-brightness,) var(--tw-contrast,) var(--tw-grayscale,) var(--tw-hue-rotate,) var(--tw-invert,) var(--tw-saturate,) var(--tw-sepia,) var(--tw-drop-shadow,)}.backdrop-filter{-webkit-backdrop-filter:var(--tw-backdrop-blur,) var(--tw-backdrop-brightness,) var(--tw-backdrop-contrast,) var(--tw-backdrop-grayscale,) var(--tw-backdrop-hue-rotate,) var(--tw-backdrop-invert,) var(--tw-backdrop-opacity,) var(--tw-backdrop-saturate,) var(--tw-backdrop-sepia,);backdrop-filter:var(--tw-backdrop-blur,) var(--tw-backdrop-brightness,) var(--tw-backdrop-contrast,) var(--tw-backdrop-grayscale,) var(--tw-backdrop-hue-rotate,) var(--tw-backdrop-invert,) var(--tw-backdrop-opacity,) var(--tw-backdrop-saturate,) var(--tw-backdrop-sepia,)}@media (min-width:40rem){.sm\:px-8{padding-inline:calc(var(--spacing) * 8)}.sm\:text-left{text-align:left}.sm\:text-5xl{font-size:var(--text-5xl);line-height:var(--tw-leading,var(--text-5xl--line-height))}}}:root{--background:#fff;--foreground:#1a1a1a}body{background:var(--background);color:var(--foreground);font-family:var(--font-geist-sans), Arial, Helvetica, sans-serif}.mesh-page{--mesh-bg:#f6f8fb;--mesh-paper:#fff;--mesh-ink:#111827;--mesh-muted:#5b6472;--mesh-soft:#e5ebf3;--mesh-accent:#2454c6;--mesh-teal:#0f766e;--mesh-amber:#b7791f;--mesh-rose:#b33b55;--mesh-shadow:0 24px 60px #0f172a1a;min-height:100vh;color:var(--mesh-ink);font-family:var(--font-geist-sans), Arial, Helvetica, sans-serif;background:linear-gradient(#f6f8fb 0 420px,#fff 420px 100%)}.mesh-page *{box-sizing:border-box}.mesh-page a{color:inherit}.mesh-text-link{color:var(--mesh-accent);text-underline-offset:3px;text-decoration:none;transition:color .16s,text-decoration-color .16s}.mesh-text-link:hover{color:#163f9a;text-decoration:underline}.mesh-wiki-link{vertical-align:super;color:#7b8493;font-family:var(--font-geist-mono), monospace;margin-left:.18rem;font-size:.58rem;font-weight:700;text-decoration:none}.mesh-wiki-link:hover{color:var(--mesh-rose);text-decoration:underline}.mesh-hero-band{border-bottom:1px solid var(--mesh-soft);background:var(--mesh-bg)}.mesh-hero{grid-template-columns:minmax(0,1.05fr) minmax(300px,.85fr);gap:2.1rem;width:min(1180px,100% - 40px);margin:0 auto;padding:2.45rem 0 2.85rem;display:grid}.mesh-breadcrumb{color:var(--mesh-muted);flex-wrap:wrap;grid-column:1/-1;align-items:center;gap:.2rem;font-size:.78rem;line-height:1.5;display:flex}.mesh-breadcrumb-root{color:var(--mesh-ink);font-weight:700}.mesh-breadcrumb-code{color:#87909f;font-family:var(--font-geist-mono), monospace;margin-left:.35rem;font-weight:500}.mesh-breadcrumb-item{align-items:baseline;display:inline-flex}.mesh-breadcrumb-sep{color:#a2aab7;margin:0 .45rem}.mesh-breadcrumb-current{color:var(--mesh-ink);font-weight:700}.mesh-title-block{align-self:center}.mesh-kicker{color:var(--mesh-accent);font-family:var(--font-geist-mono), monospace;letter-spacing:.12em;text-transform:uppercase;margin:0 0 .75rem;font-size:.7rem;font-weight:800}.mesh-title-block h1{max-width:11ch;color:var(--mesh-ink);font-family:var(--font-source-serif), Georgia, serif;letter-spacing:0;margin:0;font-size:3.35rem;font-weight:780;line-height:.98}.mesh-dek{color:#303947;max-width:62ch;font-family:var(--font-source-serif), Georgia, serif;margin:1rem 0 0;font-size:1.08rem;line-height:1.55}.mesh-journal-strip{color:var(--mesh-muted);flex-wrap:wrap;gap:.55rem .8rem;margin-top:1.35rem;font-size:.76rem;font-weight:650;display:flex}.mesh-journal-strip span{align-items:center;display:inline-flex}.mesh-journal-strip span:not(:last-child):after{content:"/";color:#b5bdc9;margin-left:.8rem;font-weight:500}.mesh-metric-grid{grid-template-columns:repeat(4,minmax(0,1fr));gap:.8rem;margin:1.45rem 0 0;display:grid}.mesh-metric{border:1px solid #dbe3ef;border-left:3px solid var(--mesh-accent);background:#ffffffd1;border-radius:8px;min-width:0;padding:.72rem .8rem;transition:transform .16s,border-color .16s,box-shadow .16s;box-shadow:0 12px 30px #0f172a0d}.mesh-metric:nth-child(2){border-left-color:var(--mesh-teal)}.mesh-metric:nth-child(3){border-left-color:var(--mesh-amber)}.mesh-metric:nth-child(4){border-left-color:var(--mesh-rose)}.mesh-metric:hover{border-color:#c9d5e6;transform:translateY(-2px);box-shadow:0 18px 38px #0f172a17}.mesh-metric dt{color:#667085;letter-spacing:.08em;text-transform:uppercase;margin:0 0 .28rem;font-size:.62rem;font-weight:760}.mesh-metric dd{color:var(--mesh-ink);font-family:var(--font-geist-mono), monospace;overflow-wrap:anywhere;margin:0;font-size:.88rem;font-weight:720;line-height:1.35}.mesh-metric-note{color:var(--mesh-muted);margin-top:.25rem;font-size:.66rem;line-height:1.35;display:block}.mesh-hero-visual{background:var(--mesh-paper);box-shadow:var(--mesh-shadow);border:1px solid #d8e1ed;border-radius:8px;flex-direction:column;align-self:stretch;margin:0;display:flex;overflow:hidden}.mesh-hero-visual img{object-fit:contain;object-position:center;background:#fff;flex:auto;width:100%;height:100%;min-height:300px;max-height:520px;display:block}.mesh-hero-visual figcaption{color:var(--mesh-muted);border-top:1px solid #edf1f6;justify-content:space-between;align-items:center;gap:1rem;padding:.85rem 1rem;font-size:.8rem;display:flex}.mesh-hero-visual figcaption span{font-family:var(--font-geist-mono), monospace}.mesh-hero-visual figcaption a{color:var(--mesh-accent);font-weight:760;text-decoration:none}.mesh-hero-visual figcaption a:hover{text-decoration:underline}.mesh-hero-record{background:var(--mesh-paper);box-shadow:var(--mesh-shadow);border:1px solid #d8e1ed;border-radius:8px;align-content:center;align-self:stretch;gap:.65rem;padding:2rem;display:grid}.mesh-hero-record span{color:var(--mesh-accent);font-family:var(--font-geist-mono), monospace;font-size:.8rem;font-weight:800}.mesh-hero-record strong{font-family:var(--font-source-serif), Georgia, serif;font-size:2.25rem;line-height:1.05}.mesh-hero-record p{color:var(--mesh-muted);margin:0}.mesh-layout{grid-template-columns:230px minmax(0,780px);align-items:start;gap:3.25rem;width:min(1180px,100% - 40px);min-width:0;max-width:100%;margin:0 auto;padding:3rem 0 5rem;display:grid}.mesh-layout>*{min-width:0}.mesh-rail{gap:1rem;min-width:0;max-width:100%;display:grid;position:sticky;top:1.25rem}.mesh-rail-label{color:#6f7785;font-family:var(--font-geist-mono), monospace;letter-spacing:.11em;text-transform:uppercase;margin:0 0 .7rem;font-size:.68rem;font-weight:800}.mesh-section-nav,.mesh-source-card{background:var(--mesh-paper);border:1px solid #dde5f0;border-radius:8px;min-width:0;max-width:100%;padding:1rem;box-shadow:0 14px 38px #0f172a0f}.mesh-section-nav ol{gap:.25rem;min-width:0;max-width:100%;margin:0;padding:0;list-style:none;display:grid}.mesh-section-nav a{color:#3f4857;border-radius:6px;grid-template-columns:2.3rem minmax(0,1fr);align-items:baseline;gap:.45rem;padding:.48rem .5rem;font-size:.82rem;font-weight:680;line-height:1.25;text-decoration:none;transition:background .16s,color .16s,transform .16s;display:grid}.mesh-section-nav a span{color:#9aa3b1;font-family:var(--font-geist-mono), monospace;font-size:.7rem}.mesh-section-nav a:hover{color:var(--mesh-accent);background:#f1f5fa;transform:translate(2px)}.mesh-source-card dl{gap:.8rem;margin:0;display:grid}.mesh-source-card div{min-width:0}.mesh-source-card dt{color:#717b8b;letter-spacing:.08em;text-transform:uppercase;font-size:.68rem;font-weight:760}.mesh-source-card dd{color:var(--mesh-ink);font-family:var(--font-geist-mono), monospace;overflow-wrap:anywhere;margin:.2rem 0 0;font-size:.78rem;line-height:1.45}.mesh-article-body{min-width:0}.mesh-section{border-top:1px solid #e2e8f1;padding:2.25rem 0;scroll-margin-top:1.5rem;position:relative}.mesh-section:first-child{border-top:0;padding-top:0}.mesh-section:target{animation:.9s ease-out mesh-target}@keyframes mesh-target{0%{background:#2454c617;box-shadow:0 0 0 16px #2454c617}to{background:0 0;box-shadow:0 0 #2454c600}}.mesh-section-heading{gap:.25rem;margin-bottom:.9rem;display:grid}.mesh-section-eyebrow{color:var(--mesh-accent);font-family:var(--font-geist-mono), monospace;letter-spacing:.11em;text-transform:uppercase;margin:0;font-size:.62rem;font-weight:850}.mesh-section-heading h2{color:var(--mesh-ink);font-family:var(--font-source-serif), Georgia, serif;letter-spacing:0;margin:0;font-size:1.48rem;font-weight:760;line-height:1.15}.mesh-section-content{min-width:0}.mesh-prose{color:#303947;font-family:var(--font-source-serif), Georgia, serif;margin:0;font-size:1.02rem;line-height:1.72}.mesh-abstract-text{border-left:3px solid var(--mesh-accent);padding-left:1.15rem}.mesh-chem-list{background:var(--mesh-paper);border:1px solid #dbe3ef;border-radius:8px;grid-template-columns:minmax(160px,.36fr) minmax(0,1fr);margin:0;display:grid;overflow:hidden}.mesh-chem-list dt,.mesh-chem-list dd{border-bottom:1px solid #edf1f6;padding:.85rem 1rem}.mesh-chem-list dt:last-of-type,.mesh-chem-list dt:last-of-type+dd{border-bottom:0}.mesh-chem-list dt{color:#303947;background:#f7f9fc;font-size:.8rem;font-weight:780}.mesh-chem-list dd{color:#2f3744;margin:0;font-size:.94rem;line-height:1.6}.mesh-mono{font-family:var(--font-geist-mono), monospace}.mesh-break{overflow-wrap:anywhere}.mesh-model-frame{background:#f7f9fc;border:1px solid #dbe3ef;border-radius:8px;overflow:hidden;box-shadow:0 18px 48px #0f172a14}.mesh-model-frame iframe{aspect-ratio:16/10;background:#f7f9fc;border:0;width:100%;min-height:460px;display:block}.mesh-figure-note{color:var(--mesh-muted);margin:.75rem 0 0;font-size:.82rem;line-height:1.5}.mesh-subsection+.mesh-subsection{margin-top:1.4rem}.mesh-subsection h3{color:#4c5564;margin:0 0 .65rem;font-size:.9rem;font-weight:760}.mesh-chip-list{flex-wrap:wrap;gap:.55rem;margin:0;padding:0;list-style:none;display:flex}.mesh-chip{background:var(--mesh-paper);color:#344052;border:1px solid #d9e1ec;border-radius:999px;align-items:baseline;gap:.15rem;min-height:2rem;padding:.36rem .75rem;font-size:.9rem;line-height:1.25;transition:transform .15s,border-color .15s,background .15s,color .15s;display:inline-flex}.mesh-chip-link{color:var(--mesh-accent);font-weight:700;text-decoration:none}.mesh-chip:hover{background:#f7f9fc;border-color:#b9c7da;transform:translateY(-1px)}.mesh-chip-link:hover{color:#163f9a}.mesh-chip-muted{color:#4d5868;background:#f7f9fc}.mesh-disclosure{background:var(--mesh-paper);border:1px solid #dbe3ef;border-radius:8px;padding:.95rem}.mesh-disclosure summary{cursor:pointer;color:var(--mesh-ink);justify-content:space-between;align-items:center;gap:1rem;font-size:.9rem;font-weight:780;list-style:none;display:flex}.mesh-disclosure summary::-webkit-details-marker{display:none}.mesh-disclosure summary:after{content:"+";width:1.5rem;height:1.5rem;color:var(--mesh-accent);font-family:var(--font-geist-mono), monospace;border:1px solid #d1dbea;border-radius:50%;place-items:center;font-weight:800;display:inline-grid}.mesh-disclosure[open] summary{margin-bottom:.9rem}.mesh-disclosure[open] summary:after{content:"-"}.mesh-tree-list{gap:.7rem;margin:0;padding:0;list-style:none;display:grid}.mesh-tree-list li{min-width:0}.mesh-tree-path{border:1px solid #dbe3ef;border-left:3px solid var(--mesh-teal);background:var(--mesh-paper);color:#334155;font-family:var(--font-geist-mono), monospace;white-space:nowrap;border-radius:8px;padding:.78rem .9rem;font-size:.9rem;line-height:1.7;display:block;overflow-x:auto}.mesh-tree-segment{align-items:baseline;display:inline-flex}.mesh-tree-dot{color:#a4adba}.mesh-call-number{color:#334155;font-family:var(--font-geist-mono), monospace;background:#f7f9fc;border:1px solid #dbe3ef;border-radius:6px;margin:0;padding:.55rem .75rem;font-size:.95rem;display:inline-block}.mesh-references{color:#333b48;font-family:var(--font-source-serif), Georgia, serif;margin:0;padding-left:1.35rem;font-size:1rem;line-height:1.75}.mesh-references a{overflow-wrap:anywhere}.mesh-references li{margin-bottom:.75rem;padding-left:.35rem}.mesh-references li::marker{color:#737d8b;font-family:var(--font-geist-mono), monospace;font-size:.86rem}@media (max-width:1060px){.mesh-hero,.mesh-layout{width:min(100% - 32px,860px)}.mesh-hero{grid-template-columns:1fr}.mesh-title-block h1{max-width:none;font-size:2.85rem}.mesh-layout{grid-template-columns:1fr;gap:1.75rem}.mesh-rail{position:static}.mesh-section-nav{overflow:hidden}.mesh-section-nav ol{gap:.4rem;width:100%;max-width:100%;padding-bottom:.2rem;display:flex;overflow-x:auto}.mesh-section-nav li{flex:none}.mesh-section-nav a{white-space:nowrap;grid-template-columns:auto 1fr}}@media (max-width:760px){.mesh-page{background:var(--mesh-bg)}.mesh-hero{gap:1.15rem;width:min(100% - 24px,640px);padding:1.45rem 0 1.7rem}.mesh-title-block h1{font-size:2.1rem;line-height:1.02}.mesh-dek{margin-top:.8rem;font-size:.98rem;line-height:1.5}.mesh-metric-grid{grid-template-columns:repeat(2,minmax(0,1fr));gap:.55rem;margin-top:1rem}.mesh-hero-visual img{min-height:185px}.mesh-hero-visual figcaption{flex-direction:column;align-items:flex-start;gap:.45rem}.mesh-layout{width:min(100% - 24px,640px);padding:.85rem 0 2.5rem}.mesh-section{padding:1.55rem 0}.mesh-section-heading h2{font-size:1.24rem;line-height:1.18}.mesh-prose{font-size:.98rem;line-height:1.65}.mesh-chem-list{grid-template-columns:1fr}.mesh-chem-list dt{border-bottom:0;padding-bottom:.25rem}.mesh-chem-list dd{padding-top:.25rem}.mesh-model-frame iframe{aspect-ratio:1;min-height:340px}}@media (max-width:460px){.mesh-metric-grid{grid-template-columns:repeat(2,minmax(0,1fr))}.mesh-breadcrumb{font-size:.7rem;line-height:1.35}.mesh-kicker{margin-bottom:.55rem;font-size:.64rem}.mesh-title-block h1{font-size:1.9rem}.mesh-journal-strip{gap:.35rem .55rem;margin-top:.95rem;font-size:.7rem}.mesh-journal-strip span:not(:last-child):after{margin-left:.55rem}.mesh-metric{padding:.62rem .68rem}.mesh-metric dd{font-size:.82rem}.mesh-metric-note{font-size:.62rem}.mesh-section-nav,.mesh-source-card,.mesh-disclosure{padding:.85rem}}@media (prefers-reduced-motion:reduce){.mesh-page *,.mesh-page :before,.mesh-page :after{transition-duration:.01ms!important;animation-duration:.01ms!important;animation-iteration-count:1!important}}.mesh-graph{flex-direction:column;gap:.85rem;display:flex}.mesh-graph-legend{flex-wrap:wrap;gap:.4rem;display:flex}.mesh-graph-chip{border:1px solid var(--mesh-soft);background:var(--mesh-paper);color:var(--mesh-ink);cursor:pointer;border-radius:999px;align-items:center;gap:.4rem;padding:.28rem .6rem;font-size:.74rem;font-weight:500;line-height:1;transition:border-color .16s,background .16s,opacity .16s;display:inline-flex}.mesh-graph-chip:hover{border-color:#c3ccda}.mesh-graph-chip.is-off{opacity:.42;text-decoration:line-through}.mesh-graph-swatch{border-radius:50%;flex:none;width:.7rem;height:.7rem}.mesh-graph-canvas{aspect-ratio:760/520;border:1px solid var(--mesh-soft);touch-action:none;-webkit-user-select:none;user-select:none;background:radial-gradient(circle at 50% 42%,#fff 0,#f7f9fc 70%,#eef2f8 100%);border-radius:14px;width:100%;height:auto}.mesh-graph-canvas a{cursor:pointer}.mesh-graph-label{fill:var(--mesh-ink);font-family:var(--font-geist-sans), Arial, sans-serif;paint-order:stroke;stroke:#fff;stroke-width:3.5px;stroke-linejoin:round;font-size:13px;font-weight:600}.mesh-graph-hint{color:var(--mesh-muted);font-size:.76rem}@media (max-width:460px){.mesh-graph-label{font-size:15px}}@property --tw-rotate-x{syntax:"*";inherits:false}@property --tw-rotate-y{syntax:"*";inherits:false}@property --tw-rotate-z{syntax:"*";inherits:false}@property --tw-skew-x{syntax:"*";inherits:false}@property --tw-skew-y{syntax:"*";inherits:false}@property --tw-border-style{syntax:"*";inherits:false;initial-value:solid}@property --tw-leading{syntax:"*";inherits:false}@property --tw-font-weight{syntax:"*";inherits:false}@property --tw-tracking{syntax:"*";inherits:false}@property --tw-outline-style{syntax:"*";inherits:false;initial-value:solid}@property --tw-blur{syntax:"*";inherits:false}@property --tw-brightness{syntax:"*";inherits:false}@property --tw-contrast{syntax:"*";inherits:false}@property --tw-grayscale{syntax:"*";inherits:false}@property --tw-hue-rotate{syntax:"*";inherits:false}@property --tw-invert{syntax:"*";inherits:false}@property --tw-opacity{syntax:"*";inherits:false}@property --tw-saturate{syntax:"*";inherits:false}@property --tw-sepia{syntax:"*";inherits:false}@property --tw-drop-shadow{syntax:"*";inherits:false}@property --tw-drop-shadow-color{syntax:"*";inherits:false}@property --tw-drop-shadow-alpha{syntax:"<percentage>";inherits:false;initial-value:100%}@property --tw-drop-shadow-size{syntax:"*";inherits:false}@property --tw-backdrop-blur{syntax:"*";inherits:false}@property --tw-backdrop-brightness{syntax:"*";inherits:false}@property --tw-backdrop-contrast{syntax:"*";inherits:false}@property --tw-backdrop-grayscale{syntax:"*";inherits:false}@property --tw-backdrop-hue-rotate{syntax:"*";inherits:false}@property --tw-backdrop-invert{syntax:"*";inherits:false}@property --tw-backdrop-opacity{syntax:"*";inherits:false}@property --tw-backdrop-saturate{syntax:"*";inherits:false}@property --tw-backdrop-sepia{syntax:"*";inherits:false}