Structured Summary
Abstract
An enediyne that alkylates DNA and RNA like MITOMYCIN does, so it is cytotoxic.
Chemical Identity
Chemical Information
- Molecular Formula
- C35H35NO12
- Molecular Weight
- 661.6 g/mol
- CAS Registry No.
- 9014-02-2
- IUPAC Name
- [(4S,11R,12R)-11-[(2R,3R,4R,5R,6R)-4,5-dihydroxy-6-methyl-3-(methylamino)oxan-2-yl]oxy-4-(2-oxo-1,3-dioxolan-4-yl)-5-oxatricyclo[8.3.0.04,6]tridec-1(13)-en-2,7-diyn-12-yl] 2-hydroxy-7-methoxy-5-methylnaphthalene-1-carboxylate
- InChIKey
- BLXZMHNVKCEIJX-LTZUVELHSA-N
- SMILES
- C[C@@H]1[C@@H]([C@@H]([C@H]([C@H](O1)O[C@H]2[C@@H](C=C3C2CC#CC4[C@@](O4)(C#C3)C5COC(=O)O5)OC(=O)C6=C(C=CC7=C6C=C(C=C7C)OC)O)NC)O)O
- MeSH Unique ID
- D009353
- Source
- PubChem CID 57125363
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
1 entry terms
- Neocarzinostatin
MeSH Record
Aspects Covered
26 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
93; was NEOCARZINOSTATIN 1975-92 (see under ANTIBIOTICS, ANTINEOPLASTIC 1975-90)
MeSH Record
Previous Indexing
- Antibiotics, Antineoplastic (1971-1974)
- Bacterial Proteins (1974)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Zinostatin. Medical Subject Headings (MeSH). 2026. Unique ID D009353. http://id.nlm.nih.gov/mesh/2026/D009353
- Zinostatin. In: Wikipedia. https://en.wikipedia.org/wiki/Neocarzinostatin
- Zinostatin. In: Wikidata. https://www.wikidata.org/wiki/Q205145
- Zinostatin. In: PubChem Compound. CID 57125363. https://pubchem.ncbi.nlm.nih.gov/compound/57125363