Chemicals and Drugs

Zinc Finger Protein Gli3

A zinc finger transcription factor that contains five CYS2-HIS2 ZINC FINGERS and binds to the GLI consensus sequence 5'-GGGTGGTC-3'. The full-length protein functions as a transcriptional activator whereas the truncated C-terminal form functions as a transcriptional repressor of the Sonic Hedgehog (Shh) signaling pathway; a balance between these two forms is critical for limb and digit development. GLI3 also plays a critical role in the differentiation and proliferation of CHONDROCYTES.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A zinc finger transcription factor that contains five CYS2-HIS2 ZINC FINGERS and binds to the GLI consensus sequence 5'-GGGTGGTC-3'. The full-length protein functions as a transcriptional activator whereas the truncated C-terminal form functions as a transcriptional repressor of the Sonic Hedgehog (Shh) signaling pathway; a balance between these two forms is critical for limb and digit development. GLI3 also plays a critical role in the differentiation and proliferation of CHONDROCYTES.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

4 entry terms
  • GLI-Kruppel Family Member 3 Protein
  • Glioma-Associated Oncogene Family Zinc Finger 3 Protein
  • GLI Kruppel Family Member 3 Protein
  • Glioma Associated Oncogene Family Zinc Finger 3 Protein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • DNA-Binding Proteins (1990-2017)
  • Kruppel-Like Transcription Factors (2006-2017)
  • Nerve Tissue Proteins (2006-2017)
  • Transcription Factors (1990-2017)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.260w.522w.875
  2. D12.776w.260w.703.900
  3. D12.776w.930w.375w.875
  4. D12.776w.930w.780.972

AMA Style

References

  1. National Library of Medicine. Zinc Finger Protein Gli3. Medical Subject Headings (MeSH). 2026. Unique ID D000074290. http://id.nlm.nih.gov/mesh/2026/D000074290
  2. Zinc Finger Protein Gli3. In: Wikidata. https://www.wikidata.org/wiki/Q24739509