Chemicals and Drugs

X-ray Repair Cross Complementing Protein 1

A poly(ADP)-ribose-binding protein that functions in the rejoining of DNA single-strand breaks that arise following treatment with alkylating agents or ionizing radiation. It interacts with DNA LIGASE III and POLY ADP RIBOSE POLYMERASE in BASE EXCISION REPAIR, and may also function in DNA processing and chromosome recombination in GERM CELLS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A poly(ADP)-ribose-binding protein that functions in the rejoining of DNA single-strand breaks that arise following treatment with alkylating agents or ionizing radiation. It interacts with DNA LIGASE III and POLY ADP RIBOSE POLYMERASE in BASE EXCISION REPAIR, and may also function in DNA processing and chromosome recombination in GERM CELLS.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

3 entry terms
  • XRCC1 DNA Repair Protein
  • XRCC1 Protein
  • X ray Repair Cross Complementing Protein 1

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018 (1994)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.157w.687.813
  2. D12.776w.260w.963
  3. D12.776w.660w.720.813

AMA Style

References

  1. National Library of Medicine. X-ray Repair Cross Complementing Protein 1. Medical Subject Headings (MeSH). 2026. Unique ID D000076105. http://id.nlm.nih.gov/mesh/2026/D000076105
  2. X-ray Repair Cross Complementing Protein 1. In: Wikidata. https://www.wikidata.org/wiki/Q83135476