Chemicals and Drugs

X-linked Nuclear Protein

ATP-dependent DNA helicase that contains two N-terminal ZINC FINGERS and C-terminal ATP-binding and helicase domains. It functions in the regulation of gene transcription and CHROMATIN REMODELING. ATRX undergoes cell-cycle dependent phosphorylation, which causes it to translocate from the NUCLEAR MATRIX to CHROMATIN; thus, it may change its role from gene regulation during INTERPHASE to ensuring proper chromosome segregation at MITOSIS. Mutations in the ATRX gene are associated with cases of X-LINKED MENTAL RETARDATION co-morbid with ALPHA-THALASSEMIA (ATRX syndrome).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

ATP-dependent DNA helicase that contains two N-terminal ZINC FINGERS and C-terminal ATP-binding and helicase domains. It functions in the regulation of gene transcription and CHROMATIN REMODELING. ATRX undergoes cell-cycle dependent phosphorylation, which causes it to translocate from the NUCLEAR MATRIX to CHROMATIN; thus, it may change its role from gene regulation during INTERPHASE to ensuring proper chromosome segregation at MITOSIS. Mutations in the ATRX gene are associated with cases of X-LINKED MENTAL RETARDATION co-morbid with ALPHA-THALASSEMIA (ATRX syndrome).

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See Also

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Synonyms

5 entry terms
  • ATRX Protein
  • RAD54 Homolog Protein
  • Homolog Protein, RAD54
  • Nuclear Protein, X-linked
  • X linked Nuclear Protein

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • DNA Helicases (1995-2017)
  • Nuclear Proteins (1995-2017)

MeSH Hierarchy

Tree Number

  1. D08.811w.399w.340.375

AMA Style

References

  1. National Library of Medicine. X-linked Nuclear Protein. Medical Subject Headings (MeSH). 2026. Unique ID D000075924. http://id.nlm.nih.gov/mesh/2026/D000075924
  2. X-linked Nuclear Protein. In: Wikidata. https://www.wikidata.org/wiki/Q21105313