Diseases

Williams Syndrome

A disorder caused by hemizygous microdeletion of about 28 genes on chromosome 7q11.23, including the ELASTIN gene. Clinical manifestations include SUPRAVALVULAR AORTIC STENOSIS; MENTAL RETARDATION; elfin facies; impaired visuospatial constructive abilities; and transient HYPERCALCEMIA in infancy. The condition affects both sexes, with onset at birth or in early infancy.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A disorder caused by hemizygous microdeletion of about 28 genes on chromosome 7q11.23, including the ELASTIN gene. Clinical manifestations include SUPRAVALVULAR AORTIC STENOSIS; MENTAL RETARDATION; elfin facies; impaired visuospatial constructive abilities; and transient HYPERCALCEMIA in infancy. The condition affects both sexes, with onset at birth or in early infancy.

MeSH Record

Classification

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See Also

MeSH Record

Synonyms

17 entry terms
  • Beuren Syndrome
  • Chromosome 7q11.23 Deletion Syndrome
  • Contiguous Gene Syndrome, Williams
  • Hypercalcemia-Supravalvar Aortic Stenosis
  • Supravalvar Aortic Stenosis Syndrome
  • Williams Contiguous Gene Syndrome
  • Williams-Beuren Syndrome
  • Aortic Stenoses, Hypercalcemia-Supravalvar
  • Aortic Stenosis, Hypercalcemia-Supravalvar
  • Hypercalcemia Supravalvar Aortic Stenosis
  • Hypercalcemia-Supravalvar Aortic Stenoses
  • Stenoses, Hypercalcemia-Supravalvar Aortic
  • Stenosis, Hypercalcemia-Supravalvar Aortic
  • Syndrome, Beuren
  • Syndrome, Williams
  • Syndrome, Williams-Beuren
  • Williams Beuren Syndrome

MeSH Record

Aspects Covered

34 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

Indexing Annotation

do not confuse with Williams-Campbell syndrome, a congenital cartilage deficiency

MeSH Record

History Note

96

MeSH Record

Previous Indexing

  • Aortic Valve Stenosis (1969-1995)

MeSH Hierarchy

Tree Numbers

AMA Style

References

  1. National Library of Medicine. Williams Syndrome. Medical Subject Headings (MeSH). 2026. Unique ID D018980. http://id.nlm.nih.gov/mesh/2026/D018980
  2. Williams Syndrome. In: Wikipedia. https://en.wikipedia.org/wiki/Williams_syndrome
  3. Williams Syndrome. In: Wikidata. https://www.wikidata.org/wiki/Q558077