Chemicals and Drugs

WNK Lysine-Deficient Protein Kinase 1

A serine-threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. It functions as an activator and inhibitor of sodium-coupled chloride co-transporters and as an inhibitor of potassium-coupled chloride co-transporters. Mutations in the WNK1 gene are associated with type 2C PSEUDOHYPOALDOSTERONISM and type 2A HEREDITARY SENSORY AND AUTONOMIC NEUROPATHIES.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A serine-threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. It functions as an activator and inhibitor of sodium-coupled chloride co-transporters and as an inhibitor of potassium-coupled chloride co-transporters. Mutations in the WNK1 gene are associated with type 2C PSEUDOHYPOALDOSTERONISM and type 2A HEREDITARY SENSORY AND AUTONOMIC NEUROPATHIES.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

1 entry terms
  • WNK Lysine Deficient Protein Kinase 1

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • Intracellular Signaling Peptides and Proteins (2005-2017)
  • Minor Histocompatibility Antigens (2005-2017)
  • Protein-Serine-Threonine Kinases (2005-2017)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.700w.982
  2. D12.776w.476.563w.982
  3. D23.050w.301.500.600w.962
  4. D23.050w.705.552.600w.925

AMA Style

References

  1. National Library of Medicine. WNK Lysine-Deficient Protein Kinase 1. Medical Subject Headings (MeSH). 2026. Unique ID D000076204. http://id.nlm.nih.gov/mesh/2026/D000076204
  2. WNK Lysine-Deficient Protein Kinase 1. In: Wikidata. https://www.wikidata.org/wiki/Q21103058