Chemicals and Drugs

Vindesine

Vinblastine derivative with antineoplastic activity against CANCER. Major side effects are myelosuppression and neurotoxicity. Vindesine is used extensively in chemotherapy protocols (ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Vinblastine derivative with antineoplastic activity against CANCER. Major side effects are myelosuppression and neurotoxicity. Vindesine is used extensively in chemotherapy protocols (ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS).

Chemical Identity

Chemical Information

Molecular Formula
C43H55N5O7
Molecular Weight
753.9 g/mol
CAS Registry No.
53643-48-4
IUPAC Name
methyl (13S,15S,17S)-13-[(1R,9R,10S,11R,12R,19R)-10-carbamoyl-12-ethyl-10,11-dihydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-17-ethyl-17-hydroxy-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraene-13-carboxylate
InChIKey
HHJUWIANJFBDHT-KOTLKJBCSA-N
SMILES
CC[C@@]1(C[C@@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)N)O)O)CC)OC)C(=O)OC)O
MeSH Unique ID
D014751
Source
PubChem CID 40839

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

10 entry terms
  • Desacetylvinblastine Amide
  • Vindesin
  • Compound 112531
  • Eldisine
  • Enison
  • NSC-245467
  • Vindesine Sulfate
  • NSC 245467
  • NSC245467
  • Sulfate, Vindesine

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

86

MeSH Record

Previous Indexing

  • Vinblastine/analogs & derivatives (1980-1985)
  • Vinca Alkaloids (1973-1979)

MeSH Hierarchy

Tree Numbers

  1. D03w.132w.436w.681.827w.830w
  2. D03w.633.100.473.402w.681.827w.830w
  3. D03w.633.100.496.500.500w.681.827w.830w

AMA Style

References

  1. National Library of Medicine. Vindesine. Medical Subject Headings (MeSH). 2026. Unique ID D014751. http://id.nlm.nih.gov/mesh/2026/D014751
  2. Vindesine. In: Wikipedia. https://en.wikipedia.org/wiki/Vindesine
  3. Vindesine. In: Wikidata. https://www.wikidata.org/wiki/Q416660
  4. Vindesine. In: PubChem Compound. CID 40839. https://pubchem.ncbi.nlm.nih.gov/compound/40839