Chemicals and Drugs

Valosin Containing Protein

A highly-conserved AAA ATPase that functions in the biogenesis of the transitional ENDOPLASMIC RETICULUM and fragmentation and reassembly of the GOLGI APPARATUS during MITOSIS. It also functions in a complex with UFD1L and NPLOC4 proteins to export misfolded ubiquitinated proteins from the endoplasmic reticulum and outer mitochondrial membrane to the cytoplasm for degradation by the PROTEASOME and also plays a role in AUTOPHAGY of ubiquitinated proteins. It occurs in neuronal INCLUSION BODIES from patients with AMYOTROPHIC LATERAL SCLEROSIS and LEWY BODIES from PARKINSON DISEASE patients.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A highly-conserved AAA ATPase that functions in the biogenesis of the transitional ENDOPLASMIC RETICULUM and fragmentation and reassembly of the GOLGI APPARATUS during MITOSIS. It also functions in a complex with UFD1L and NPLOC4 proteins to export misfolded ubiquitinated proteins from the endoplasmic reticulum and outer mitochondrial membrane to the cytoplasm for degradation by the PROTEASOME and also plays a role in AUTOPHAGY of ubiquitinated proteins. It occurs in neuronal INCLUSION BODIES from patients with AMYOTROPHIC LATERAL SCLEROSIS and LEWY BODIES from PARKINSON DISEASE patients.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

9 entry terms
  • CDC48 Protein
  • Cell Cycle Protein CDC48
  • Cell Cycle Protein CDC48p
  • Valosin-Containing Protein
  • Valosine-Containing Protein
  • p97 Valosin-Containing Protein
  • Valosin-Containing Protein, p97
  • Valosine Containing Protein
  • p97 Valosin Containing Protein

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018 (1991)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.040w.013w.500.750
  2. D08.811w.277w.040w.025w.024.750
  3. D12.776w.157w.025w.750.750
  4. D12.776w.167.800

AMA Style

References

  1. National Library of Medicine. Valosin Containing Protein. Medical Subject Headings (MeSH). 2026. Unique ID D000074405. http://id.nlm.nih.gov/mesh/2026/D000074405
  2. Valosin Containing Protein. In: Wikidata. https://www.wikidata.org/wiki/Q24781881