Structured Summary
Abstract
A highly conserved 76-amino acid peptide universally found in eukaryotic cells that functions as a marker for intracellular PROTEIN TRANSPORT and degradation. Ubiquitin becomes activated through a series of complicated steps and forms an isopeptide bond to lysine residues of specific proteins within the cell. These ubiquitinated proteins can be recognized and degraded by proteosomes or be transported to specific compartments within the cell.
MeSH Record
Classification
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MeSH Record
Synonyms
7 entry terms
- APF-1
- ATP-Dependent Proteolysis Factor 1
- HMG-20
- High Mobility Protein 20
- ATP Dependent Proteolysis Factor 1
- Ubiquitin, Human
- Human Ubiquitin
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
Indexing Annotation
UBIQUITINS is also available
MeSH Record
History Note
2002; use UBIQUITINS (1985-2001)
MeSH Record
Previous Indexing
- Chromosomal Proteins, Non-Histone (1977-1984)
- Nucleoproteins (1966-1977)
- Peptides (1975-1980)
- Ubiquitins (1985-2001)
MeSH Hierarchy
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AMA Style
References
- National Library of Medicine. Ubiquitin. Medical Subject Headings (MeSH). 2026. Unique ID D025801. http://id.nlm.nih.gov/mesh/2026/D025801
- Ubiquitin. In: Wikipedia. https://en.wikipedia.org/wiki/Ubiquitin
- Ubiquitin. In: Wikidata. https://www.wikidata.org/wiki/Q407111