Chemicals and Drugs

U4-U6 Small Nuclear Ribonucleoprotein

A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U4-U6 snRNP along with the U5 snRNP preassemble into a single 25S particle that binds to the U1 and U2 snRNPs and the substrate to form mature SPLICEOSOMES. There is also evidence for the existence of individual U4 or U6 snRNPs in addition to their organization as a U4-U6 snRNP.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U4-U6 snRNP along with the U5 snRNP preassemble into a single 25S particle that binds to the U1 and U2 snRNPs and the substrate to form mature SPLICEOSOMES. There is also evidence for the existence of individual U4 or U6 snRNPs in addition to their organization as a U4-U6 snRNP.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

16 entry terms
  • Ribonucleoprotein, U4-U6 Small Nuclear
  • Ribonucleoproteins, Small, U4-U6
  • Small Nuclear Ribonucleoproteins, U4-U6
  • U4-U6 Small Nuclear Ribonucleoproteins
  • U4-U6 snRNP
  • Ribonucleoprotein, U4 U6 Small Nuclear
  • Small Nuclear Ribonucleoproteins, U4 U6
  • U4 U6 Small Nuclear Ribonucleoproteins
  • Ribonucleoproteins, U4 Small Nuclear
  • Ribonucleoproteins, U6 Small Nuclear
  • Small Nuclear Ribonucleoproteins, U4
  • Small Nuclear Ribonucleoproteins, U6
  • U4 Small Nuclear Ribonucleoproteins
  • U4 snRNP
  • U6 Small Nuclear Ribonucleoproteins
  • U6 snRNP

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2000; U4 SNRNP was U4 RNP (SY) to SMALL NUCLEAR RIBONUCLEOPROTEINS (NM) 1982-92; U6 SNRNP was U6 RNP (SY) to SMALL NUCLEAR RIBONUCLEOPROTEINS (NM) 1982-92

MeSH Record

Previous Indexing

  • Ribonucleoproteins (1982-1992)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.157w.725w.500w.875w.615
  2. D12.776w.664w.962w.500w.875w.615

AMA Style

References

  1. National Library of Medicine. U4-U6 Small Nuclear Ribonucleoprotein. Medical Subject Headings (MeSH). 2026. Unique ID D017414. http://id.nlm.nih.gov/mesh/2026/D017414
  2. U4-U6 Small Nuclear Ribonucleoprotein. In: Wikidata. https://www.wikidata.org/wiki/Q78115358