Chemicals and Drugs

U2 Small Nuclear Ribonucleoprotein

A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U2 snRNP along with other small nuclear ribonucleoproteins (U1, U4-U6, and U5) assemble into SPLICEOSOMES that remove introns from pre-mRNA by splicing. The U2 snRNA forms base pairs with conserved sequence motifs at the branch point, which associates with a heat- and RNAase-sensitive factor in an early step of splicing.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U2 snRNP along with other small nuclear ribonucleoproteins (U1, U4-U6, and U5) assemble into SPLICEOSOMES that remove introns from pre-mRNA by splicing. The U2 snRNA forms base pairs with conserved sequence motifs at the branch point, which associates with a heat- and RNAase-sensitive factor in an early step of splicing.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

5 entry terms
  • Ribonucleoprotein, U2 Small Nuclear
  • Ribonucleoproteins, Small, U2
  • Small Nuclear Ribonucleoproteins, U2
  • U2 Small Nuclear Ribonucleoproteins
  • U2 snRNP

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2000; U2 SNRNP was SNRNP-U2 (SY) to SMALL RIBONUCLEOPROTEINS (NM) 1982-92

MeSH Record

Previous Indexing

  • Ribonucleoproteins (1975-1992)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.157w.725w.500w.875w.605
  2. D12.776w.157w.725w.829w.344
  3. D12.776w.664w.962w.500w.875w.605
  4. D12.776w.664w.962w.829w.344

AMA Style

References

  1. National Library of Medicine. U2 Small Nuclear Ribonucleoprotein. Medical Subject Headings (MeSH). 2026. Unique ID D017413. http://id.nlm.nih.gov/mesh/2026/D017413
  2. U2 Small Nuclear Ribonucleoprotein. In: Wikidata. https://www.wikidata.org/wiki/Q22328852