Chemicals and Drugs

Type VI Secretion Systems

Multiprotein complexes in GRAM NEGATIVE BACTERIA that deliver effector proteins into eukaryotic or prokaryotic cells by a mechanism similar to the contractile tail of bacteriophages. They are composed of a cell envelope-spanning tube which is surrounded by a contractile sheath and tipped by a cell puncturing complex; a base plate structure that anchors the assembly to the cell envelope; and an ATPase involved in the sheath contraction and disassembly of the complex.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Multiprotein complexes in GRAM NEGATIVE BACTERIA that deliver effector proteins into eukaryotic or prokaryotic cells by a mechanism similar to the contractile tail of bacteriophages. They are composed of a cell envelope-spanning tube which is surrounded by a contractile sheath and tipped by a cell puncturing complex; a base plate structure that anchors the assembly to the cell envelope; and an ATPase involved in the sheath contraction and disassembly of the complex.

MeSH Record

Classification

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MeSH Record

Synonyms

7 entry terms
  • Bacterial Secretion System, Type VI
  • T6SS Secretion Systems
  • Type 6 Secretion System
  • Type 6 Secretion Systems
  • Type VI Secretion System
  • Secretion Systems, T6SS
  • Systems, T6SS Secretion

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2016

MeSH Record

Previous Indexing

  • Bacterial Secretion Systems (2010-2015)

MeSH Hierarchy

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AMA Style

References

  1. National Library of Medicine. Type VI Secretion Systems. Medical Subject Headings (MeSH). 2026. Unique ID D000069376. http://id.nlm.nih.gov/mesh/2026/D000069376
  2. Type VI Secretion Systems. In: Wikidata. https://www.wikidata.org/wiki/Q68538343