Chemicals and Drugs

Type VII Secretion Systems

Bacterial secretion systems found in bacteria that have a MYCOLIC ACID-containing outer membrane such as MYCOBACTERIACEAE; Corynebacteriaceae; and NOCARDIACEAE. These are also known as ESX secretion systems because the first to be discovered is involved in secreting major virulence factors EsxA and EsxB. There are several subtypes of T7SSs including ESX-1, ESX-2, ESX-3, ESX-4, and ESX-5 secretion systems. The subtypes share some core components including an inner membrane channel-forming ATPase complex, a membrane-anchored mycosin, and a second channel that spans the outer mycolic acid-containing membrane.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Bacterial secretion systems found in bacteria that have a MYCOLIC ACID-containing outer membrane such as MYCOBACTERIACEAE; Corynebacteriaceae; and NOCARDIACEAE. These are also known as ESX secretion systems because the first to be discovered is involved in secreting major virulence factors EsxA and EsxB. There are several subtypes of T7SSs including ESX-1, ESX-2, ESX-3, ESX-4, and ESX-5 secretion systems. The subtypes share some core components including an inner membrane channel-forming ATPase complex, a membrane-anchored mycosin, and a second channel that spans the outer mycolic acid-containing membrane.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

14 entry terms
  • ESX Secretion System
  • ESX Secretion Systems
  • Secretion Systems, ESX
  • Secretion Systems, Type 7
  • Secretion Systems, Type VII
  • T7SS Secretion System
  • Type 7 Secretion System
  • Type 7 Secretion Systems
  • Type VII Secretion System
  • Secretion System, ESX
  • Secretion System, T7SS
  • System, ESX Secretion
  • System, T7SS Secretion
  • Systems, ESX Secretion

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2016

MeSH Record

Previous Indexing

  • Bacterial Secretion Systems (2010-2015)

MeSH Hierarchy

Tree Number

  1. D05.500w.890.500w.992

AMA Style

References

  1. National Library of Medicine. Type VII Secretion Systems. Medical Subject Headings (MeSH). 2026. Unique ID D000069377. http://id.nlm.nih.gov/mesh/2026/D000069377
  2. Type VII Secretion Systems. In: Wikidata. https://www.wikidata.org/wiki/Q77446011