Chemicals and Drugs

Type II Site-Specific Deoxyribonucleases

Enzyme systems containing a single subunit and requiring only magnesium for endonucleolytic activity. The corresponding modification methylases are separate enzymes. The systems recognize specific short DNA sequences and cleave either within, or at a short specific distance from, the recognition sequence to give specific double-stranded fragments with terminal 5'-phosphates. Enzymes from different microorganisms with the same specificity are called isoschizomers. EC 3.1.21.4.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Enzyme systems containing a single subunit and requiring only magnesium for endonucleolytic activity. The corresponding modification methylases are separate enzymes. The systems recognize specific short DNA sequences and cleave either within, or at a short specific distance from, the recognition sequence to give specific double-stranded fragments with terminal 5'-phosphates. Enzymes from different microorganisms with the same specificity are called isoschizomers. EC 3.1.21.4.

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Synonyms

14 entry terms
  • DNA Restriction Enzymes, Type II
  • DNase, Site Specific, Type II
  • DNase, Site-Specific, Type II
  • Deoxyribonucleases, Type II Site-Specific
  • Deoxyribonucleases, Type II, Site Specific
  • Deoxyribonucleases, Type II, Site-Specific
  • Restriction Endonucleases, Type II
  • Site-Specific DNase, Type II
  • Type II Restriction Enzymes
  • Type II Site Specific DNase
  • Type II Site Specific Deoxyribonucleases
  • Type II Site-Specific DNase
  • Deoxyribonucleases, Type II Site Specific
  • Site Specific DNase, Type II

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

89

MeSH Record

Previous Indexing

  • DNA Restriction Enzymes (1978-1988)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.150w.280w.260w
  2. D08.811w.277w.352w.335w.350w.300w.260w
  3. D08.811w.277w.352w.355w.325w.300w.260w

AMA Style

References

  1. National Library of Medicine. Type II Site-Specific Deoxyribonucleases. Medical Subject Headings (MeSH). 2026. Unique ID D015252. http://id.nlm.nih.gov/mesh/2026/D015252
  2. Type II Site-Specific Deoxyribonucleases. In: Wikipedia. https://en.wikipedia.org/wiki/Type_II_site-specific_deoxyribonuclease
  3. Type II Site-Specific Deoxyribonucleases. In: Wikidata. https://www.wikidata.org/wiki/Q22327032