Chemicals and Drugs

Type III Site-Specific Deoxyribonucleases

Enzyme systems composed of two subunits and requiring ATP and magnesium for endonucleolytic activity; they do not function as ATPases. They exist as complexes with modification methylases of similar specificity listed under EC 2.1.1.72 or EC 2.1.1.73. The systems recognize specific short DNA sequences and cleave a short distance, about 24 to 27 bases, away from the recognition sequence to give specific double-stranded fragments with terminal 5'-phosphates. Enzymes from different microorganisms with the same specificity are called isoschizomers. EC 3.1.21.5.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Enzyme systems composed of two subunits and requiring ATP and magnesium for endonucleolytic activity; they do not function as ATPases. They exist as complexes with modification methylases of similar specificity listed under EC 2.1.1.72 or EC 2.1.1.73. The systems recognize specific short DNA sequences and cleave a short distance, about 24 to 27 bases, away from the recognition sequence to give specific double-stranded fragments with terminal 5'-phosphates. Enzymes from different microorganisms with the same specificity are called isoschizomers. EC 3.1.21.5.

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Synonyms

14 entry terms
  • DNA Restriction Enzymes, Type III
  • DNase, Site Specific, Type III
  • DNase, Site-Specific, Type III
  • Deoxyribonucleases, Type III Site-Specific
  • Deoxyribonucleases, Type III, Site Specific
  • Deoxyribonucleases, Type III, Site-Specific
  • Restriction Endonucleases, Type III
  • Site-Specific DNase, Type III
  • Type III Restriction Enzymes
  • Type III Site Specific DNase
  • Type III Site Specific Deoxyribonucleases
  • Type III Site-Specific DNase
  • Deoxyribonucleases, Type III Site Specific
  • Site Specific DNase, Type III

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

89

MeSH Record

Previous Indexing

  • DNA Restriction Enzymes (1975-1988)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.150w.280w.270w
  2. D08.811w.277w.352w.335w.350w.300w.270w
  3. D08.811w.277w.352w.355w.325w.300w.270w

AMA Style

References

  1. National Library of Medicine. Type III Site-Specific Deoxyribonucleases. Medical Subject Headings (MeSH). 2026. Unique ID D015263. http://id.nlm.nih.gov/mesh/2026/D015263
  2. Type III Site-Specific Deoxyribonucleases. In: Wikipedia. https://en.wikipedia.org/wiki/Type_III_site-specific_deoxyribonuclease
  3. Type III Site-Specific Deoxyribonucleases. In: Wikidata. https://www.wikidata.org/wiki/Q22326537