Chemicals and Drugs

Type 6 Cyclic Nucleotide Phosphodiesterases

A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in the outer segment PHOTORECEPTOR CELLS of the RETINA. It is comprised of two catalytic subunits, referred to as alpha and beta, that form a dimer. In addition two regulatory subunits, referred to as gamma and delta, modulate the activity and localization of the enzyme.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in the outer segment PHOTORECEPTOR CELLS of the RETINA. It is comprised of two catalytic subunits, referred to as alpha and beta, that form a dimer. In addition two regulatory subunits, referred to as gamma and delta, modulate the activity and localization of the enzyme.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

32 entry terms
  • Cyclic Nucleotide Phosphodiesterases, Type 6
  • PDE6 Phosphodiesterases
  • Phosphodiesterase 6
  • Phosphodiesterase Type 6
  • Retinal Phosphodiesterase 6
  • Phosphodiesterase 6, Retinal
  • Phosphodiesterases, PDE6
  • Cyclic Nucleotide Phosphodiesterases, Type 6, alpha Subunit
  • Cyclic Nucleotide Phosphodiesterases, Type 6, beta Subunit
  • Cyclic Nucleotide Phosphodiesterases, Type 6, delta Subunit
  • Cyclic Nucleotide Phosphodiesterases, Type 6, gamma Subunit
  • PDE6, alpha Subunit
  • PDE6, beta Subunit
  • PDE6, delta Subunit
  • Retinal Phosphodiesterase, alpha Subunit
  • Retinal Phosphodiesterase, beta Subunit
  • Retinal Phosphodiesterase, delta Subunit
  • Rod cGMP Phosphodiesterase, beta Subunit
  • alpha Subunit, PDE6
  • beta Subunit, PDE6
  • cGMP Phosphodiesterase delta Subunit
  • cGMP-PDE gamma Subunit
  • delta Subunit, PDE6
  • gamma Subunit, cGMP Phosphodiesterase
  • PDE6 alpha Subunit
  • PDE6 beta Subunit
  • PDE6 delta Subunit
  • alpha Subunit PDE6
  • beta Subunit PDE6
  • cGMP PDE gamma Subunit
  • delta Subunit PDE6
  • gamma Subunit, cGMP-PDE

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2008(2001)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.352w.640.150w.600
  2. D08.811w.277w.352w.640.155w.750
  3. D12.776w.476.008w.600
  4. D12.776w.476.009w.750

AMA Style

References

  1. National Library of Medicine. Type 6 Cyclic Nucleotide Phosphodiesterases. Medical Subject Headings (MeSH). 2026. Unique ID D054707. http://id.nlm.nih.gov/mesh/2026/D054707
  2. Type 6 Cyclic Nucleotide Phosphodiesterases. In: Wikidata. https://www.wikidata.org/wiki/Q77393879