Chemicals and Drugs

Type 4 Cyclic Nucleotide Phosphodiesterases

A cyclic nucleotide phosphodiesterase subfamily that is found predominantly in inflammatory cells and may play a role in the regulation of CELL-MEDIATED IMMUNITY. The enzyme family includes over twenty different variants that occur due to multiple ALTERNATIVE SPLICING of the mRNA of at least four different genes.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A cyclic nucleotide phosphodiesterase subfamily that is found predominantly in inflammatory cells and may play a role in the regulation of CELL-MEDIATED IMMUNITY. The enzyme family includes over twenty different variants that occur due to multiple ALTERNATIVE SPLICING of the mRNA of at least four different genes.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

Synonyms

23 entry terms
  • Cyclic Nucleotide Phosphodiesterase PDE4 Family
  • Cyclic Nucleotide Phosphodiesterases, Type 4
  • PDE4 Phosphodiesterases
  • Phosphodiesterase 4
  • Phosphodiesterase IV
  • Phosphodiesterase-4
  • Type 4 Cyclic Nucleotide Phosphodiesterase
  • Phosphodiesterases, PDE4
  • Cyclic Nucleotide Phosphodiesterases, Type 4A
  • Cyclic Nucleotide Phosphodiesterases, Type 4A5
  • Cyclic Nucleotide Phosphodiesterases, Type 4B
  • Cyclic Nucleotide Phosphodiesterases, Type 4C
  • Cyclic Nucleotide Phosphodiesterases, Type 4D
  • Cyclic Nucleotide Phosphodiesterases, Type 4D3
  • PDE4D3 Phosphodiesterase
  • Phosphodiesterase 4A
  • Phosphodiesterase 4B
  • Phosphodiesterase 4C
  • Phosphodiesterase 4D
  • cAMP-Specific Phosphodiesterase 4A5
  • Phosphodiesterase 4A5, cAMP-Specific
  • Phosphodiesterase, PDE4D3
  • cAMP Specific Phosphodiesterase 4A5

MeSH Record

Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2008(1981)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.352w.640.150w.400w
  2. D12.776w.476.008w.400w

AMA Style

References

  1. National Library of Medicine. Type 4 Cyclic Nucleotide Phosphodiesterases. Medical Subject Headings (MeSH). 2026. Unique ID D054703. http://id.nlm.nih.gov/mesh/2026/D054703
  2. Type 4 Cyclic Nucleotide Phosphodiesterases. In: Wikipedia. https://en.wikipedia.org/wiki/Phosphodiesterase_4
  3. Type 4 Cyclic Nucleotide Phosphodiesterases. In: Wikidata. https://www.wikidata.org/wiki/Q26261890