Chemicals and Drugs

Type 2 Cyclic Nucleotide Phosphodiesterases

A cyclic nucleotide phosphodiesterase subfamily that is activated by the binding of CYCLIC GMP to an allosteric domain found on the enzyme. Multiple enzyme variants of this subtype can be produced due to multiple alternative mRNA splicing. The subfamily is expressed in a broad variety of tissues and may play a role in mediating cross-talk between CYCLIC GMP and CYCLIC CMP pathways. Although the type 2 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), members of this class have additional specificity for CYCLIC GMP.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A cyclic nucleotide phosphodiesterase subfamily that is activated by the binding of CYCLIC GMP to an allosteric domain found on the enzyme. Multiple enzyme variants of this subtype can be produced due to multiple alternative mRNA splicing. The subfamily is expressed in a broad variety of tissues and may play a role in mediating cross-talk between CYCLIC GMP and CYCLIC CMP pathways. Although the type 2 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), members of this class have additional specificity for CYCLIC GMP.

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Classification

Broader headings

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MeSH Record

Synonyms

12 entry terms
  • Cyclic GMP-Stimulated Phosphodiesterase
  • Cyclic Nucleotide Phosphodiesterase PDE2 Family
  • Cyclic Nucleotide Phosphodiesterases, Type 2
  • PDE2 Phosphodiesterase
  • PDE2 Phosphodiesterases
  • Cyclic GMP Stimulated Phosphodiesterase
  • Phosphodiesterase, Cyclic GMP-Stimulated
  • Cyclic Nucleotide Phosphodiesterases, Type 2A
  • Phosphodiesterase 2A
  • cGMP-Dependent 3',5'-Cyclic Phosphodiesterase
  • 3',5'-Cyclic Phosphodiesterase, cGMP-Dependent
  • cGMP Dependent 3',5' Cyclic Phosphodiesterase

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2008(2000)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.352w.640.150w.200w
  2. D08.811w.277w.352w.640.155w.200w
  3. D12.776w.476.008w.200w
  4. D12.776w.476.009w.200w

AMA Style

References

  1. National Library of Medicine. Type 2 Cyclic Nucleotide Phosphodiesterases. Medical Subject Headings (MeSH). 2026. Unique ID D054678. http://id.nlm.nih.gov/mesh/2026/D054678
  2. Type 2 Cyclic Nucleotide Phosphodiesterases. In: Wikipedia. https://en.wikipedia.org/wiki/Phosphodiesterase_2
  3. Type 2 Cyclic Nucleotide Phosphodiesterases. In: Wikidata. https://www.wikidata.org/wiki/Q5864328