Chemicals and Drugs

Type 1 Cyclic Nucleotide Phosphodiesterases

A CALCIUM and CALMODULIN-dependent cyclic nucleotide phosphodiesterase subfamily. The three members of this family are referred to as type 1A, type 1B, and type 1C and are each product of a distinct gene. In addition, multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing. Although the type 1 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), some members of this class have additional specificity for CYCLIC GMP.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A CALCIUM and CALMODULIN-dependent cyclic nucleotide phosphodiesterase subfamily. The three members of this family are referred to as type 1A, type 1B, and type 1C and are each product of a distinct gene. In addition, multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing. Although the type 1 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), some members of this class have additional specificity for CYCLIC GMP.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

33 entry terms
  • Ca(2+)-CaM-Stimulated PDE
  • Ca++ Calmodulin Dependent Cyclic AMP Phosphodiesterase
  • Ca-CaM-Phosphodiesterase
  • Calcium-Calmodulin-Dependent Phosphodiesterase
  • Calcium-Calmodulin-Stimulated Cyclic AMP Phosphodiesterase
  • Calmodulin Phosphodiesterase
  • Calmodulin-Dependent Phosphodiesterase
  • Calmodulin-Dependent cGMP Phosphodiesterase
  • Cyclic Nucleotide Phosphodiesterase PDE1 Family
  • Cyclic Nucleotide Phosphodiesterases, Type 1
  • Cyclic Nucleotide Phosphodiesterases, Type I
  • PDE1 Phosphodiesterases
  • Ca CaM Phosphodiesterase
  • Calcium Calmodulin Dependent Phosphodiesterase
  • Calcium Calmodulin Stimulated Cyclic AMP Phosphodiesterase
  • Calmodulin Dependent Phosphodiesterase
  • Calmodulin Dependent cGMP Phosphodiesterase
  • Phosphodiesterase, Calcium-Calmodulin-Dependent
  • Phosphodiesterase, Calmodulin-Dependent cGMP
  • Phosphodiesterases, PDE1
  • cGMP Phosphodiesterase, Calmodulin-Dependent
  • Cyclic Nucleotide Phosphodiesterases, Type 1A
  • Cyclic Nucleotide Phosphodiesterases, Type 1B
  • Cyclic Nucleotide Phosphodiesterases, Type 1C
  • Phosphodiesterase 1A, Calmodulin-Dependent
  • Phosphodiesterase 1B, Calmodulin-Dependent
  • Phosphodiesterase 1C, Calmodulin-Dependent
  • Calmodulin-Dependent Phosphodiesterase 1A
  • Calmodulin-Dependent Phosphodiesterase 1B
  • Calmodulin-Dependent Phosphodiesterase 1C
  • Phosphodiesterase 1A, Calmodulin Dependent
  • Phosphodiesterase 1B, Calmodulin Dependent
  • Phosphodiesterase 1C, Calmodulin Dependent

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2008(1981) for CA++ CALMODULIN DEPENDENT CYCLIC AMP PHOSPHODIESTERASE use 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1986-2007, for CALMODULIN PHOSPHODIESTERASE use 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1981-2007, for CALMODULIN-DEPENDENT PHOSPHODIESTERASE use 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1984-2007

MeSH Record

Previous Indexing

  • 3',5'-Cyclic-GMP Phosphodiesterases (1981-2007)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.352w.640.150w.100
  2. D08.811w.277w.352w.640.155w.100
  3. D12.776w.476.008w.100
  4. D12.776w.476.009w.100

AMA Style

References

  1. National Library of Medicine. Type 1 Cyclic Nucleotide Phosphodiesterases. Medical Subject Headings (MeSH). 2026. Unique ID D054677. http://id.nlm.nih.gov/mesh/2026/D054677
  2. Type 1 Cyclic Nucleotide Phosphodiesterases. In: Wikidata. https://www.wikidata.org/wiki/Q100598278