Chemicals and Drugs

Tumor Suppressor Protein p14ARF

A gene product of the p16 tumor suppressor gene (GENES, P16). It antagonizes the function of MDM2 PROTEIN (which regulates P53 TUMOR SUPPRESSOR PROTEIN by targeting it for degradation). p14ARF is produced from the beta mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced alpha transcript, is CYCLIN-DEPENDENT KINASE INHIBITOR P16. Both p16 gene products have tumor suppressor functions.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A gene product of the p16 tumor suppressor gene (GENES, P16). It antagonizes the function of MDM2 PROTEIN (which regulates P53 TUMOR SUPPRESSOR PROTEIN by targeting it for degradation). p14ARF is produced from the beta mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced alpha transcript, is CYCLIN-DEPENDENT KINASE INHIBITOR P16. Both p16 gene products have tumor suppressor functions.

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Synonyms

5 entry terms
  • Cdkn2a(p14ARF)
  • p(ARF) Protein
  • p14(ARF)
  • p14ARF
  • p14ARF Protein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2002(1996)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.167.600
  2. D12.776w.624.776.772

AMA Style

References

  1. National Library of Medicine. Tumor Suppressor Protein p14ARF. Medical Subject Headings (MeSH). 2026. Unique ID D025803. http://id.nlm.nih.gov/mesh/2026/D025803
  2. Tumor Suppressor Protein p14ARF. In: Wikidata. https://www.wikidata.org/wiki/Q24774050