Chemicals and Drugs

Tuberous Sclerosis Complex 1 Protein

An intracellular signaling and tumor suppressor protein that forms a complex with TUBEROUS SCLEROSIS COMPLEX 2 PROTEIN (TSC2) and other signaling factors to negatively regulate MTORC1 signaling and affect cell growth and proliferation. Structurally, it interacts with TSC2 through its N-terminal, which also contains GSK-3BETA phosphorylation sites and a RHO-KINASE activation domain. It also contains a C-terminal coiled-coil domain and ezrin-radixin-moesin (ERM) domain. Mutations in the TSC1 gene are associated with TUBEROUS SCLEROSIS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An intracellular signaling and tumor suppressor protein that forms a complex with TUBEROUS SCLEROSIS COMPLEX 2 PROTEIN (TSC2) and other signaling factors to negatively regulate MTORC1 signaling and affect cell growth and proliferation. Structurally, it interacts with TSC2 through its N-terminal, which also contains GSK-3BETA phosphorylation sites and a RHO-KINASE activation domain. It also contains a C-terminal coiled-coil domain and ezrin-radixin-moesin (ERM) domain. Mutations in the TSC1 gene are associated with TUBEROUS SCLEROSIS.

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Synonyms

1 entry terms
  • Hamartin

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Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2019 (1997)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.360.925w
  2. D12.776w.476.932w
  3. D12.776w.624.776.766w

AMA Style

References

  1. National Library of Medicine. Tuberous Sclerosis Complex 1 Protein. Medical Subject Headings (MeSH). 2026. Unique ID D000077004. http://id.nlm.nih.gov/mesh/2026/D000077004
  2. Tuberous Sclerosis Complex 1 Protein. In: Wikipedia. https://en.wikipedia.org/wiki/TSC1
  3. Tuberous Sclerosis Complex 1 Protein. In: Wikidata. https://www.wikidata.org/wiki/Q898669