Chemicals and Drugs

Troponin I

A TROPONIN complex subunit that inhibits ACTOMYOSIN ATPASE activity thereby disrupting ACTIN and MYOSIN interaction. There are three troponin I subtypes: troponin I1, I2 and I3. Troponin I3 is cardiac-specific whereas troponin I1 and I2 are skeletal subtypes. Troponin I3 is a BIOMARKER for damaged or injured CARDIAC MYOCYTES and mutations in troponin I3 gene are associated with FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A TROPONIN complex subunit that inhibits ACTOMYOSIN ATPASE activity thereby disrupting ACTIN and MYOSIN interaction. There are three troponin I subtypes: troponin I1, I2 and I3. Troponin I3 is cardiac-specific whereas troponin I1 and I2 are skeletal subtypes. Troponin I3 is a BIOMARKER for damaged or injured CARDIAC MYOCYTES and mutations in troponin I3 gene are associated with FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

4 entry terms
  • Troponin-I
  • Troponin I1
  • Troponin I2
  • Troponin I3

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

TROPONIN C & TROPONIN T are also available

MeSH Record

History Note

97; was TROPONIN I (NM) 1975-96

MeSH Record

Previous Indexing

  • Muscle Proteins (1975-1978)
  • Troponin (1979-1996)

MeSH Hierarchy

Tree Numbers

  1. D05.500w.945w.925w
  2. D05.750w.078w.730.825w.925w
  3. D12.776w.210.500.910w.925w
  4. D12.776w.220.525.825w.925w

AMA Style

References

  1. National Library of Medicine. Troponin I. Medical Subject Headings (MeSH). 2026. Unique ID D019210. http://id.nlm.nih.gov/mesh/2026/D019210
  2. Troponin I. In: Wikipedia. https://en.wikipedia.org/wiki/Troponin_I
  3. Troponin I. In: Wikidata. https://www.wikidata.org/wiki/Q7846263