Diseases

Trisomy 18 Syndrome

A chromosome disorder associated with TRISOMY of all or part of CHROMOSOME 18. Clinical manifestations include INTRAUTERINE GROWTH RETARDATION; CLEFT PALATE; CONGENITAL HEART DEFECTS; MICROCEPHALY; MICROGNATHIA and clenched fists with overlapping fingers. Most affected fetuses do not survive to birth. Those who survive through their first year often have severe INTELLECTUAL DISABILITY.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A chromosome disorder associated with TRISOMY of all or part of CHROMOSOME 18. Clinical manifestations include INTRAUTERINE GROWTH RETARDATION; CLEFT PALATE; CONGENITAL HEART DEFECTS; MICROCEPHALY; MICROGNATHIA and clenched fists with overlapping fingers. Most affected fetuses do not survive to birth. Those who survive through their first year often have severe INTELLECTUAL DISABILITY.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

6 entry terms
  • Trisomy 18 Syndromes
  • Complete Trisomy 18 Syndrome
  • Edwards Syndrome
  • Mosaic Trisomy 18 Syndrome
  • Trisomy 18
  • Trisomy E Syndrome

MeSH Record

Aspects Covered

34 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

2018

MeSH Hierarchy

Tree Numbers

  1. C14w.240.400w.975w
  2. C14w.280w.400w.975w
  3. C16w.131w.077w.929w
  4. C16w.131w.240.400w.968w
  5. C16w.131w.260w.932w
  6. C16w.320w.180w.932w

AMA Style

References

  1. National Library of Medicine. Trisomy 18 Syndrome. Medical Subject Headings (MeSH). 2026. Unique ID D000073842. http://id.nlm.nih.gov/mesh/2026/D000073842
  2. Trisomy 18 Syndrome. In: Wikipedia. https://en.wikipedia.org/wiki/Trisomy_18
  3. Trisomy 18 Syndrome. In: Wikidata. https://www.wikidata.org/wiki/Q457737